I M Goodyer1, J Herbert, A Tamplin, P M Altham. 1. Developmental Psychiatry Section, Department of Psychiatry, Cambridge Clinical School, University of Cambridge, and Lifespan Healthcare Trust, England.
Abstract
BACKGROUND: It is not clear whether cortisol or dehydroepiandrosterone (DHEA) hypersecretion increases the risk for major depression in the presence of undesirable life events. AIMS: To determine whether there is a specific pattern of psychoendocrine factors that predicts the onset of major depressive disorder. METHOD: 180 adolescents (73 boys, 107 girls) at high risk for psychopathology were assessed for cortisol, DHEA, depressive symptoms, life events and psychiatric disorder at entry and 12 months later. RESULTS: Major depression was predicted for both genders by the additive effects of: higher depressive symptoms; personal disappointments and losses only in the month before onset; one or more daily levels of cortisol at 08.00 h or DHEA at 20.00 h greater than the 80th percentile of the daily mean. CONCLUSIONS: A subgroup of adolescents may carry a physiological risk for major depression which may be either of genetic and/or earlier psychosocial origin.
BACKGROUND: It is not clear whether cortisol or dehydroepiandrosterone (DHEA) hypersecretion increases the risk for major depression in the presence of undesirable life events. AIMS: To determine whether there is a specific pattern of psychoendocrine factors that predicts the onset of major depressive disorder. METHOD: 180 adolescents (73 boys, 107 girls) at high risk for psychopathology were assessed for cortisol, DHEA, depressive symptoms, life events and psychiatric disorder at entry and 12 months later. RESULTS: Major depression was predicted for both genders by the additive effects of: higher depressive symptoms; personal disappointments and losses only in the month before onset; one or more daily levels of cortisol at 08.00 h or DHEA at 20.00 h greater than the 80th percentile of the daily mean. CONCLUSIONS: A subgroup of adolescents may carry a physiological risk for major depression which may be either of genetic and/or earlier psychosocial origin.
Authors: Paula D Riggs; Laetitia L Thompson; Susan F Tapert; Joseph Frascella; Susan Mikulich-Gilbertson; Manish Dalwani; Mark Laudenslager; Michelle Lohman Journal: Drug Alcohol Depend Date: 2007-12-01 Impact factor: 4.492
Authors: Brandon L Goldstein; Greg Perlman; Roman Kotov; Joan E Broderick; Keke Liu; Camilo Ruggero; Daniel N Klein Journal: J Affect Disord Date: 2016-10-11 Impact factor: 4.839