| Literature DB >> 11101813 |
A G Gao1, S M Hakimi, C A Mittanck, Y Wu, B M Woerner, D M Stark, D M Shah, J Liang, C M Rommens.
Abstract
Defensins are small cysteine-rich peptides with antimicrobial activity. We demonstrate that the alfalfa antifungal peptide (alfAFP) defensin isolated from seeds of Medicago sativa displays strong activity against the agronomically important fungal pathogen Verticillium dahliae. Expression of the alfAFP peptide in transgenic potato plants provides robust resistance in the greenhouse. Importantly, this resistance is maintained under field conditions. There have been no previous demonstrations of a single transgene imparting a disease resistance phenotype that is at least equivalent to those achieved through current practices using fumigants.Entities:
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Year: 2000 PMID： 11101813 DOI： 10.1038/82436
Source DB: PubMed Journal: Nat Biotechnol ISSN： 1087-0156 Impact factor: 54.908