Literature DB >> 11101425

Design, synthesis, and evaluation of a pyrrolinone-based matrix metalloprotease inhibitor.

A B Smith1, T Nittoli, P A Sprengeler, J J Duan, R Q Liu, R F Hirschmann.   

Abstract

[reaction: see text] A pyrrolinone-based hydroxamate matrix metalloprotease inhibitor, (-)-1, has been designed and synthesized. Enzymatic assay revealed that (-)-1 inhibited three of the ten matrix metalloprotease enzymes examined and as such represents a new, potentially important lead structure.

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Year:  2000        PMID： 11101425     DOI： 10.1021/ol000254p

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  3 in total

1.  Pyrrolinone-based peptidomimetics. "Let the enzyme or receptor be the judge".

Authors:  Amos B Smith; Adam K Charnley; Ralph Hirschmann
Journal:  Acc Chem Res       Date:  2010-12-22       Impact factor: 22.384

2.  Design, synthesis, and structural analysis of D,L-mixed polypyrrolinones. 1. From nonpeptide peptidomimetics to nanotubes.

Authors:  Amos B Smith; Wenyong Wang; Adam K Charnley; Patrick J Carroll; Craig S Kenesky; Ralph Hirschmann
Journal:  Org Lett       Date:  2010-07-02       Impact factor: 6.005

3.  Design, synthesis, and structural analysis of D,L-mixed polypyrrolinones. 2. Macrocyclic hexapyrrolinones.

Authors:  Amos B Smith; Hui Xiong; Adam K Charnley; Meinrad Brenner; Eugen F Mesaros; Craig S Kenesky; Luigi Di Costanzo; David W Christianson; Ralph Hirschmann
Journal:  Org Lett       Date:  2010-07-02       Impact factor: 6.005
  3 in total

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