Epidemiology and pathogenesis of sleep-disordered breathing.

Sleep-disordered breathing is common in the general population, but the observed prevalence depends on the criteria used to establish the diagnosis. Obesity is a strong risk factor, but other conditions such as allergic upper and lower airways disease may also be important. Differences in risk between the sexes and ethnic groups appear to be present even after established risk factors have been considered. The pathogenesis is likely mutifactorial with anatomic and physiologic factors of varying importance in different individuals. The natural history is uncertain, but without treatment or reduction in risk factors, some progression is likely. Ongoing epidemiologic investigations such as the Sleep Heart Health Study are beginning to provide important information on these questions.