Literature DB >> 11100146

Presynaptic calcium stores underlie large-amplitude miniature IPSCs and spontaneous calcium transients.

I Llano1, J González, C Caputo, F A Lai, L M Blayney, Y P Tan, A Marty.   

Abstract

The cellular mechanisms responsible for large miniature currents in some brain synapses remain undefined. In Purkinje cells, we found that large-amplitude miniature inhibitory postsynaptic currents (mIPSCs) were inhibited by ryanodine or by long-term removal of extracellular Ca2+. Two-photon Ca2+ imaging revealed random, ryanodine-sensitive intracellular Ca2+ transients, spatially constrained at putative presynaptic terminals. At high concentration, ryanodine decreased action-potential-evoked rises in intracellular Ca2+. Immuno-localization showed ryanodine receptors in these terminals. Our data suggest that large mIPSCs are multivesicular events regulated by Ca2+ release from ryanodine-sensitive presynaptic Ca2+ stores.

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Year:  2000        PMID： 11100146     DOI： 10.1038/81781

Source DB:  PubMed          Journal:  Nat Neurosci        ISSN： 1097-6256            Impact factor:   24.884


  141 in total

1.  Assessing the role of calcium-induced calcium release in short-term presynaptic plasticity at excitatory central synapses.

Authors:  Adam G Carter; Kaspar E Vogt; Kelly A Foster; Wade G Regehr
Journal:  J Neurosci       Date:  2002-01-01       Impact factor: 6.167

2.  Fast Ca2+ signals at mouse inner hair cell synapse: a role for Ca2+-induced Ca2+ release.

Authors:  Helen J Kennedy; Robert W Meech
Journal:  J Physiol       Date:  2002-02-15       Impact factor: 5.182

3.  The high variance of AMPA receptor- and NMDA receptor-mediated responses at single hippocampal synapses: evidence for multiquantal release.

Authors:  Rossella Conti; John Lisman
Journal:  Proc Natl Acad Sci U S A       Date:  2003-04-07       Impact factor: 11.205

4.  Ca2+ syntillas, miniature Ca2+ release events in terminals of hypothalamic neurons, are increased in frequency by depolarization in the absence of Ca2+ influx.

Authors:  Valérie De Crescenzo; Ronghua ZhuGe; Cristina Velázquez-Marrero; Lawrence M Lifshitz; Edward Custer; Jeffrey Carmichael; F Anthony Lai; Richard A Tuft; Kevin E Fogarty; José R Lemos; John V Walsh
Journal:  J Neurosci       Date:  2004-02-04       Impact factor: 6.167

5.  Dark rearing alters the development of GABAergic transmission in visual cortex.

Authors:  Bernardo Morales; Se-Young Choi; Alfredo Kirkwood
Journal:  J Neurosci       Date:  2002-09-15       Impact factor: 6.167

6.  Action potential-evoked and ryanodine-sensitive spontaneous Ca2+ transients at the presynaptic terminal of a developing CNS inhibitory synapse.

Authors:  Rossella Conti; Yusuf P Tan; Isabel Llano
Journal:  J Neurosci       Date:  2004-08-04       Impact factor: 6.167

7.  Measuring action potential-evoked transmission at individual synaptic contacts.

Authors:  David W Nauen; Guo-Qiang Bi
Journal:  J Neural Eng       Date:  2012-06       Impact factor: 5.379

8.  Depolarization-induced Ca2+ entry preferentially evokes release of large quanta in the developing Xenopus neuromuscular junction.

Authors:  Xiao-Ping Sun; Bo-Ming Chen; Olav Sand; Yoshi Kidokoro; Alan D Grinnell
Journal:  J Neurophysiol       Date:  2010-09-15       Impact factor: 2.714

Review 9.  Origin of quantal size variation and high-frequency miniature postsynaptic currents at the Caenorhabditis elegans neuromuscular junction.

Authors:  Zhao-Wen Wang
Journal:  J Neurosci Res       Date:  2010-08-18       Impact factor: 4.164

10.  Altered inhibitory synaptic transmission in superficial dorsal horn neurones in spastic and oscillator mice.

Authors:  B A Graham; P R Schofield; P Sah; R J Callister
Journal:  J Physiol       Date:  2003-07-01       Impact factor: 5.182
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