Literature DB >> 11099922

Laboratory study of the effects of citric and ascorbic acids on injections prepared with brown heroin.

.   

Abstract

The addition of acidic substances to brown street heroin to facilitate the solubility of diamorphine in the injection preparation process is commonplace amongst UK injectors. Knowledge of the chemistry behind this process supports the need for this stage in the injection preparation process. It is currently illegal, under the Misuse of Drugs Act 1971, section 9A, to supply acidifiers and other paraphernalia to injectors in the UK. In the current climate of evidence-based practice, any consideration given to changing the law would look for evidence to illustrate that the paraphernalia was necessary. Although the theory behind the use of acidifiers suggests they are essential, no previous work using street heroin has actually been reported to illustrate this fact. Anecdotal information has found that drug users are being told by some service providers that the addition of acids is unnecessary. It is important that drugs services give credible information to their clients. The provision of inaccurate information in one area may lead to a lack of trust of all information provided. The small study reported here investigated, under controlled laboratory conditions, the effects of citric and ascorbic acids (vitamin C) on injections prepared with brown heroin, in order to demonstrate the need for acidifiers in the injection preparation process.

Entities:  

Year:  2000        PMID: 11099922     DOI: 10.1016/s0955-3959(00)00068-2

Source DB:  PubMed          Journal:  Int J Drug Policy        ISSN: 0955-3959


  6 in total

1.  Transmission of hepatitis C virus among people who inject drugs: viral stability and association with drug preparation equipment.

Authors:  Juliane Doerrbecker; Patrick Behrendt; Pedro Mateu-Gelabert; Sandra Ciesek; Nina Riebesehl; Corinne Wilhelm; Joerg Steinmann; Thomas Pietschmann; Eike Steinmann
Journal:  J Infect Dis       Date:  2012-11-05       Impact factor: 5.226

Review 2.  Optimising health and safety of people who inject drugs during transition from acute to outpatient care: narrative review with clinical checklist.

Authors:  Kinna Thakarar; Zoe M Weinstein; Alexander Y Walley
Journal:  Postgrad Med J       Date:  2016-03-22       Impact factor: 2.401

Review 3.  Harm Reduction Services to Prevent and Treat Infectious Diseases in People Who Use Drugs.

Authors:  Kinna Thakarar; Katherine Nenninger; Wollelaw Agmas
Journal:  Infect Dis Clin North Am       Date:  2020-09       Impact factor: 5.982

4.  Injecting-related health harms and overuse of acidifiers among people who inject heroin and crack cocaine in London: a mixed-methods study.

Authors:  Magdalena Harris; Jenny Scott; Talen Wright; Rachel Brathwaite; Daniel Ciccarone; Vivian Hope
Journal:  Harm Reduct J       Date:  2019-11-13

Review 5.  Opioids and Vitamin C: Known Interactions and Potential for Redox-Signaling Crosstalk.

Authors:  Mackenzie Newman; Heather Connery; Jonathan Boyd
Journal:  Antioxidants (Basel)       Date:  2022-06-27

6.  The impact of citrate introduction at UK syringe exchange programmes: a retrospective cohort study in Cheshire and Merseyside, UK.

Authors:  Caryl M Beynon; Jim McVeigh; Martin Chandler; Michelle Wareing; Mark A Bellis
Journal:  Harm Reduct J       Date:  2007-12-11
  6 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.