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Literature DB >> 11098887

Immunological treatments for autism.

Abstract

Several investigators, including ourselves, have reported significant changes in various immune responses in children with autism. These changes demonstrate dysregulation of the immune system (deficiency in some components of the immune system and excesses in others). In addition, certain genes in the major histocompatibility complex (that regulates immune responses) appear to be involved in autism. Based upon immunological abnormalities, various treatment modalities have been applied to children with autism. In this brief review, these immunological changes and various biological therapies are analyzed and summarized.

Entities: Disease Species

Mesh：

Substances：

Year: 2000 PMID： 11098887 DOI： 10.1023/a:1005568027292

Source DB: PubMed Journal: J Autism Dev Disord ISSN： 0162-3257

25 in total

1. Effects of pentoxifylline and theophylline on neurotransmitter uptake and release by synaptosome-rich homogenates of the rat hypothalamus.

Authors: D P Cardinali
Journal: Neuropharmacology Date: 1977-11 Impact factor: 5.250

2. Strong association of the third hypervariable region of HLA-DR beta 1 with autism.

Authors: R P Warren; J D Odell; W L Warren; R A Burger; A Maciulis; W W Daniels; A R Torres
Journal: J Neuroimmunol Date: 1996-07 Impact factor: 3.478

Review 3. Pentoxifylline: brief review and rationale for its possible use in the treatment of autism.

Authors: S Gupta; B Rimland; P D Shilling
Journal: J Child Neurol Date: 1996-11 Impact factor: 1.987

4. Possible association of the extended MHC haplotype B44-SC30-DR4 with autism.

Authors: R P Warren; V K Singh; P Cole; J D Odell; C B Pingree; W L Warren; C W DeWitt; M McCullough
Journal: Immunogenetics Date: 1992 Impact factor: 2.846

5. Increased frequency of the null allele at the complement C4b locus in autism.

Authors: R P Warren; V K Singh; P Cole; J D Odell; C B Pingree; W L Warren; E White
Journal: Clin Exp Immunol Date: 1991-03 Impact factor: 4.330

6. Antibodies to myelin basic protein in children with autistic behavior.

Authors: V K Singh; R P Warren; J D Odell; W L Warren; P Cole
Journal: Brain Behav Immun Date: 1993-03 Impact factor: 7.217

Review 7. Biology of human TH1 and TH2 cells.

Authors: S Romagnani
Journal: J Clin Immunol Date: 1995-05 Impact factor: 8.317

8. Different effects of methylxanthines on central serotonergic postsynaptic neurons in a mouse behavioral model.

Authors: T Kitatani; Y Watanabe; T Shibuya
Journal: Pharmacol Biochem Behav Date: 1993-02 Impact factor: 3.533

9. Functional deficits in autistic disorder: characterization by technetium-99m-HMPAO and SPECT.

Authors: J M Mountz; L C Tolbert; D W Lill; C R Katholi; H G Liu
Journal: J Nucl Med Date: 1995-07 Impact factor: 10.057

10. Immune abnormalities in patients with autism.

Authors: R P Warren; N C Margaretten; N C Pace; A Foster
Journal: J Autism Dev Disord Date: 1986-06

14 in total

Review 1. Complementary and alternative medicine in autism: an evidence-based approach to negotiating safe and efficacious interventions with families.

Authors: R Scott Akins; Kathy Angkustsiri; Robin L Hansen
Journal: Neurotherapeutics Date: 2010-07 Impact factor: 7.620

Review 9. What's new in autism?

Authors: Jean G Steyaert; Wouter De la Marche
Journal: Eur J Pediatr Date: 2008-07-03 Impact factor: 3.183

Review 10. Complementary and alternative medicine treatments for children with autism spectrum disorders.

Authors: Susan E Levy; Susan L Hyman
Journal: Child Adolesc Psychiatr Clin N Am Date: 2008-10

Immunological treatments for autism.

1. Effects of pentoxifylline and theophylline on neurotransmitter uptake and release by synaptosome-rich homogenates of the rat hypothalamus.

2. Strong association of the third hypervariable region of HLA-DR beta 1 with autism.

Review 3. Pentoxifylline: brief review and rationale for its possible use in the treatment of autism.

4. Possible association of the extended MHC haplotype B44-SC30-DR4 with autism.

5. Increased frequency of the null allele at the complement C4b locus in autism.

6. Antibodies to myelin basic protein in children with autistic behavior.

Review 7. Biology of human TH1 and TH2 cells.

8. Different effects of methylxanthines on central serotonergic postsynaptic neurons in a mouse behavioral model.

9. Functional deficits in autistic disorder: characterization by technetium-99m-HMPAO and SPECT.

10. Immune abnormalities in patients with autism.

Review 1. Complementary and alternative medicine in autism: an evidence-based approach to negotiating safe and efficacious interventions with families.

2. Chronomics of autism and suicide.

Review 3. Impact of Immunoglobulin Therapy in Pediatric Disease: a Review of Immune Mechanisms.

4. Brain effects of chronic IBD in areas abnormal in autism and treatment by single neuropeptides secretin and oxytocin.

Review 5. Immunological aetiology of major psychiatric disorders: evidence and therapeutic implications.

Review 6. Mesenchymal stem cells in treating autism: Novel insights.

7. Family analysis of immunoglobulin classes and subclasses in children with autistic disorder.

8. Adaptive and Innate Immune Responses in Autism: Rationale for Therapeutic Use of Intravenous Immunoglobulin.

Review 9. What's new in autism?

Review 10. Complementary and alternative medicine treatments for children with autism spectrum disorders.