Literature DB >> 11098077

Alterations of Rb, p16(INK4A) and cyclin D1 in the tumorigenesis of oral squamous cell carcinomas.

Y Nakahara1, S Shintani, M Mihara, A Kiyota, Y Ueyama, T Matsumura.   

Abstract

Immunohistochemical analysis of Rb, p16(INK4A) and cyclin D1 expression was performed on 78 oral squamous cell carcinoma (SCC), 46 leukoplakia, and 20 normal mucosa. Rb and p16(INK4A) expression were observed in all normal mucosa and most of leukoplakia. Lack of Rb and p16(INK4A) was observed in 56.4 and 67.9% of SCC, respectively. The overexpression of cyclin D1 was not observed in normal mucosa and was observed in 35.9% of SCC. A strong reciprocal relationship between Rb and p16(INK4A) expression was observed in oral SCC, and all these SCC cases have at least one of the alterations in the Rb pathway.

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Year:  2000        PMID： 11098077     DOI： 10.1016/s0304-3835(00)00546-2

Source DB:  PubMed          Journal:  Cancer Lett        ISSN： 0304-3835            Impact factor:   8.679


  11 in total

1.  CCND1 G870A polymorphism and risk for head and neck cancer: a meta-analysis.

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2.  Early Detection of Oral Squamous Cell Carcinoma (OSCC) - Role of Genetics: A Literature Review.

Authors:  C Seethalakshmi
Journal:  J Clin Diagn Res       Date:  2013-08-01

3.  Rb1/105 gene alterations and head and neck carcinogenesis.

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Journal:  Mol Biol Rep       Date:  2012-06-29       Impact factor: 2.316

4.  CCND1 amplification and cyclin D1 immunohistochemical expression in head and neck squamous cell carcinomas.

Authors:  Henning Hanken; Alexander Gröbe; Georg Cachovan; Ralf Smeets; Ronald Simon; Guido Sauter; Max Heiland; Marco Blessmann
Journal:  Clin Oral Investig       Date:  2013-03-15       Impact factor: 3.573

5.  Expressional analysis of p16 and cytokeratin19 protein in the genesis of oral squamous cell carcinoma patients.

Authors:  Ali Yousif Babiker; Arshad H Rahmani; Mohamed S Abdalaziz; Aqel Albutti; Salah M Aly; Hussain Gadelkareem Ahmed
Journal:  Int J Clin Exp Med       Date:  2014-06-15

6.  Overexpression of lecithin:retinol acyltransferase in the epithelial basal layer makes mice more sensitive to oral cavity carcinogenesis induced by a carcinogen.

Authors:  Xiao-Han Tang; Dan Su; Martin Albert; Theresa Scognamiglio; Lorraine J Gudas
Journal:  Cancer Biol Ther       Date:  2009-07-06       Impact factor: 4.742

7.  Modulations of benzo[a]pyrene-induced DNA adduct, cyclin D1 and PCNA in oral tissue by 1,4-phenylenebis(methylene)selenocyanate.

Authors:  Kun-Ming Chen; Peter G Sacks; Thomas E Spratt; Jyh-Ming Lin; Telih Boyiri; Joel Schwartz; John P Richie; Ana Calcagnotto; Arunangshu Das; James Bortner; Zonglin Zhao; Shantu Amin; Joseph Guttenplan; Karam El-Bayoumy
Journal:  Biochem Biophys Res Commun       Date:  2009-04-01       Impact factor: 3.575

8.  Correlation of clinicopathological features with immunohistochemical expression of cell cycle regulatory proteins p16 and retinoblastoma: distinct association with keratinisation and differentiation in oral cavity squamous cell carcinoma.

Authors:  D M Muirhead; H T Hoffman; R A Robinson
Journal:  J Clin Pathol       Date:  2006-02-07       Impact factor: 3.411

9.  Retinoblastoma (RB1) pocket domain mutations and promoter hyper-methylation in head and neck cancer.

Authors:  Maimoona Sabir; Ruqia Mehmood Baig; Kashif Ali; Ishrat Mahjabeen; Muhammad Saeed; Mahmood Akhtar Kayani
Journal:  Cell Oncol (Dordr)       Date:  2014-06-03       Impact factor: 6.730

10.  Overexpression of CDK2 is a prognostic indicator of oral cancer progression.

Authors:  M Mihara; S Shintani; Y Nakahara; A Kiyota; Y Ueyama; T Matsumura; D T Wong
Journal:  Jpn J Cancer Res       Date:  2001-03
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