Literature DB >> 11097846

Poly(ADP-ribose) polymerase localizes to the centrosomes and chromosomes.

M Kanai1, M Uchida, S Hanai, N Uematsu, K Uchida, M Miwa.   

Abstract

Poly(ADP-ribose) polymerase (PARP) takes part mainly in regulation of DNA repair, thereby maintaining genomic stability in the nucleus. However, what role PARP plays in mitotic cells is not known. Centrosomes play an important role in maintaining the fidelity of chromosome distribution during cell division. Loss of these functions might cause chromosomal instability and aneuploidy. p53 and BRCA1 were recently found to localize to the centrosome at mitosis. We found that PARP is localized to the centrosomes and the chromosomes at cell-division phase and interphase by indirect immunofluorescence. Furthermore, by analysis of isolated centrosomes PARP protein was found to associate with the centrosomes during mitosis. These data suggest that PARP may be involved in maintenance of chromosomal stability. Copyright 2000 Academic Press.

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Year:  2000        PMID： 11097846     DOI： 10.1006/bbrc.2000.3801

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  22 in total

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