Literature DB >> 11097090

Inhibitory effects of Indole-3-carbinol on invasion and migration in human breast cancer cells.

Q Meng1, I D Goldberg, E M Rosen, S Fan.   

Abstract

Indole-3-carbinol (I3C) is a promising phytochemical agent in chemoprevention of breast cancer. Our present study is the first description of I3C that significantly inhibits the cell adhesion, spreading and invasion associated with an up-regulation of PTEN (a tumor suppressor gene) and E-cadherin (a regulator of cell-cell adhesion) expression in T47-D human breast cancer cells. Therefore, I3C exhibits anti-cancer activities by suppressing breast tumor cell growth and metastatic spread. Metastatic breast cancer is a devastating problem, clinical application of I3C as a potent chemopreventive agent may be helpful in limiting breast cancer invasion and metastasis.

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Year:  2000        PMID： 11097090     DOI： 10.1023/a:1006495824158

Source DB:  PubMed          Journal:  Breast Cancer Res Treat        ISSN： 0167-6806            Impact factor:   4.872


  21 in total

1.  The effect of indole-3-carbinol on PIN1 and PIN2 in Arabidopsis roots.

Authors:  Ella Katz; Sophia Nisani; Mor Sela; Hila Behar; Daniel A Chamovitz
Journal:  Plant Signal Behav       Date:  2015

2.  Indole-3-carbinol suppresses NF-kappaB and IkappaBalpha kinase activation, causing inhibition of expression of NF-kappaB-regulated antiapoptotic and metastatic gene products and enhancement of apoptosis in myeloid and leukemia cells.

Authors:  Yasunari Takada; Michael Andreeff; Bharat B Aggarwal
Journal:  Blood       Date:  2005-04-05       Impact factor: 22.113

3.  Results from a dose-response study using 3,3'-diindolylmethane in the K14-HPV16 transgenic mouse model: cervical histology.

Authors:  Daniel W Sepkovic; Johann Stein; Antoine D Carlisle; H Barbara Ksieski; Karen Auborn; Laura Raucci; Themba Nyirenda; H Leon Bradlow
Journal:  Cancer Prev Res (Phila)       Date:  2011-03-07

4.  Indole-3-carbinol inhibits MDA-MB-231 breast cancer cell motility and induces stress fibers and focal adhesion formation by activation of Rho kinase activity.

Authors:  Christine T Brew; Ida Aronchik; Karena Kosco; Jasmine McCammon; Leonard F Bjeldanes; Gary L Firestone
Journal:  Int J Cancer       Date:  2009-05-15       Impact factor: 7.396

5.  Diindolylmethane inhibits cervical dysplasia, alters estrogen metabolism, and enhances immune response in the K14-HPV16 transgenic mouse model.

Authors:  Daniel W Sepkovic; Johann Stein; Antoine D Carlisle; H Barbara Ksieski; Karen Auborn; H Leon Bradlow
Journal:  Cancer Epidemiol Biomarkers Prev       Date:  2009-10-27       Impact factor: 4.254

6.  Cruciferous vegetables consumption and the risk of female lung cancer: a prospective study and a meta-analysis.

Authors:  Q J Wu; L Xie; W Zheng; E Vogtmann; H L Li; G Yang; B T Ji; Y T Gao; X O Shu; Y B Xiang
Journal:  Ann Oncol       Date:  2013-04-03       Impact factor: 32.976

7.  Indole-3-carbinol prevents PTEN loss in cervical cancer in vivo.

Authors:  Mei Qi; Ann E Anderson; Da-Zhi Chen; Shishinn Sun; Karen J Auborn
Journal:  Mol Med       Date:  2005 Jan-Dec       Impact factor: 6.354

Review 8.  Indole-3-carbinol as a chemopreventive and anti-cancer agent.

Authors:  Jing-Ru Weng; Chen-Hsun Tsai; Samuel K Kulp; Ching-Shih Chen
Journal:  Cancer Lett       Date:  2008-03-07       Impact factor: 8.679

9.  The dietary phytochemical indole-3-carbinol is a natural elastase enzymatic inhibitor that disrupts cyclin E protein processing.

Authors:  Hanh H Nguyen; Ida Aronchik; Gloria A Brar; David H H Nguyen; Leonard F Bjeldanes; Gary L Firestone
Journal:  Proc Natl Acad Sci U S A       Date:  2008-12-08       Impact factor: 11.205

10.  Loquat (Eriobotrya japonica) extracts suppress the adhesion, migration and invasion of human breast cancer cell line.

Authors:  Min-Sook Kim; Mi-Kyoung You; Dong-Young Rhuy; Yung-Jae Kim; Hum-Young Baek; Hyeon-A Kim
Journal:  Nutr Res Pract       Date:  2009-12-31       Impact factor: 1.926
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