| Literature DB >> 11097052 |
P G Baraldi1, B Cacciari, A Guiotto, R Romagnoli, G Spalluto, A Leoni, N Bianchi, G Feriotto, C Rutigliano, C Mischiati, R Gambari.
Abstract
We designed and synthesized the hybrid 6, prepared combining the minor groove binders distamycin A and pyrrolo [2,1-c][1,4] benzodiazepine (PBD) 4, related to the natural occurring anthramycin (2) and DC-81 (3). In this paper, the effects of the compound 6 on molecular interactions between DNA and transcription factor Sp1 were studied. The results obtained demonstrate that PBD-distamycin hybrid is a powerful inhibitor of Sp1/DNA interactions.Entities:
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Year: 2000 PMID： 11097052 DOI： 10.1080/15257770008033045
Source DB: PubMed Journal: Nucleosides Nucleotides Nucleic Acids ISSN： 1525-7770 Impact factor: 1.381