"Essentiality" Testing: Looking for New Antimicrobial Targets.

After a gap of some 30 years, the prospect of finding completely new agents with which to combat infectious disease is promising. New discovery approaches based on the application of genomics and associated technologies are leading to the identification of genes essential for bacterial viability and pathogenesis. This article reviews the current status of the search for new antimicrobial targets and points to future developments and issues.