PURPOSE: Glutamate antagonists can block ganglion cell death due to optic nerve crush. Although most investigators have focused on blockade of the N-methyl-D-aspartate (NMDA) subtype of glutamate receptor, we have chosen to evaluate the efficacy of blockade of the AMPA-kainate (KA) receptor in this experimental paradigm. METHODS: The optic nerves of rats were crushed, and ganglion cell survival was assessed. Groups of animals were treated with an NMDA antagonist, an AMPA-KA antagonist, or both. RESULTS: The AMPA-KA antagonist DNQX was more effective, although not additive in preserving retinal ganglion cells after optic nerve crush than the NMDA antagonist MK801. CONCLUSIONS: Activation of the AMPA-KA subtype of glutamate receptor may play a role in glutamate-mediated cell death after optic nerve crush.
PURPOSE:Glutamate antagonists can block ganglion cell death due to optic nerve crush. Although most investigators have focused on blockade of the N-methyl-D-aspartate (NMDA) subtype of glutamate receptor, we have chosen to evaluate the efficacy of blockade of the AMPA-kainate (KA) receptor in this experimental paradigm. METHODS: The optic nerves of rats were crushed, and ganglion cell survival was assessed. Groups of animals were treated with an NMDA antagonist, an AMPA-KA antagonist, or both. RESULTS: The AMPA-KA antagonist DNQX was more effective, although not additive in preserving retinal ganglion cells after optic nerve crush than the NMDA antagonist MK801. CONCLUSIONS: Activation of the AMPA-KA subtype of glutamate receptor may play a role in glutamate-mediated cell death after optic nerve crush.
Authors: Leon C Ho; Bo Wang; Ian P Conner; Yolandi van der Merwe; Richard A Bilonick; Seong-Gi Kim; Ed X Wu; Ian A Sigal; Gadi Wollstein; Joel S Schuman; Kevin C Chan Journal: Invest Ophthalmol Vis Sci Date: 2015-06 Impact factor: 4.799
Authors: Frank Schuettauf; David Zurakowski; Kristine Quinto; Meghana A Varde; Dorothea Besch; Alan Laties; Ralph Anderson; Rong Wen Journal: Graefes Arch Clin Exp Ophthalmol Date: 2005-10-20 Impact factor: 3.117
Authors: Frank Schuettauf; Sebastian Thaler; Sylvia Bolz; Julia Fries; Hubert Kalbacher; Anna Mankowska; David Zurakowski; Eberhart Zrenner; Robert Rejdak Journal: Graefes Arch Clin Exp Ophthalmol Date: 2007-08 Impact factor: 3.535