Literature DB >> 11094334

The Gas6/Axl system: a novel regulator of vascular cell function.

M G Melaragno1, Y W Fridell, B C Berk.   

Abstract

Signal transduction downstream of tyrosine kinases has become an increasingly important area of study in cardiovascular biology. In this review, we consider the experimental evidence pointing to significant roles for the Axl receptor tyrosine kinase and its ligand, Gas6, in the vasculature. An introduction to the Gas6/Axl system and a discussion of its discovery is followed by a summary of the data regarding expression of Gas6/Axl in injured arteries. We conclude by discussing mechanisms by which Gas6/Axl signaling may impact on the response of blood vessels to injury, thereby contributing to the development of atherosclerosis and/or restenosis.

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Year:  1999        PMID： 11094334     DOI： 10.1016/s1050-1738(00)00027-x

Source DB:  PubMed          Journal:  Trends Cardiovasc Med        ISSN： 1050-1738            Impact factor:   6.677


  36 in total

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2.  Age-related changes in cochlear gene expression in normal and shaker 2 mice.

Authors:  Tzy-Wen L Gong; I Jill Karolyi; James Macdonald; Lisa Beyer; Yehoash Raphael; David C Kohrman; Sally A Camper; Margaret I Lomax
Journal:  J Assoc Res Otolaryngol       Date:  2006-06-23

Review 3.  Critical signal transduction pathways in CLL.

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Review 4.  Biology of the TAM receptors.

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Journal:  Cold Spring Harb Perspect Biol       Date:  2013-11-01       Impact factor: 10.005

5.  Gas6-Axl pathway: the role of redox-dependent association of Axl with nonmuscle myosin IIB.

Authors:  Megan E Cavet; Elaine M Smolock; Prashanthi Menon; Atsushi Konishi; Vyacheslav A Korshunov; Bradford C Berk
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Authors:  Douglas K Graham; Deborah DeRyckere; Kurtis D Davies; H Shelton Earp
Journal:  Nat Rev Cancer       Date:  2014-12       Impact factor: 60.716

7.  A novel site contributing to growth-arrest-specific gene 6 binding to its receptors as revealed by a human monoclonal antibody.

Authors:  Paul W Fisher; Michael Brigham-Burke; Sheng-Jiun Wu; Jinquan Luo; Jill Carton; Kim Staquet; Wei Gao; Sheila Jackson; Deidra Bethea; Cailin Chen; Bing Hu; Jill Giles-Komar; Jing Yang
Journal:  Biochem J       Date:  2005-05-01       Impact factor: 3.857

8.  Dominant-negative inhibition of the Axl receptor tyrosine kinase suppresses brain tumor cell growth and invasion and prolongs survival.

Authors:  Peter Vajkoczy; Pjotr Knyazev; Andrea Kunkel; Hans-Holger Capelle; Sandra Behrndt; Hendrik von Tengg-Kobligk; Fabian Kiessling; Uta Eichelsbacher; Marco Essig; Tracy-Ann Read; Ralf Erber; Axel Ullrich
Journal:  Proc Natl Acad Sci U S A       Date:  2006-04-03       Impact factor: 11.205

9.  Mertk receptor mutation reduces efferocytosis efficiency and promotes apoptotic cell accumulation and plaque necrosis in atherosclerotic lesions of apoe-/- mice.

Authors:  Edward Thorp; Dongying Cui; Dorien M Schrijvers; George Kuriakose; Ira Tabas
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10.  Growth arrest-specific gene 6 (Gas6) levels are elevated in patients with chronic renal failure.

Authors:  Iris J Lee; Brendan Hilliard; Abhishek Swami; John C Madara; Swati Rao; Tapan Patel; John P Gaughan; Jean Lee; Crystal A Gadegbeku; Eric T Choi; Philip L Cohen
Journal:  Nephrol Dial Transplant       Date:  2012-08-20       Impact factor: 5.992
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