Literature DB >> 11094312

Genetic polymorphism in CYP17 and breast cancer risk in Japanese women.

Y Miyoshi1, K Iwao, N Ikeda, C Egawa, S Noguchi.   

Abstract

A case-control study was conducted to investigate the association of two genetic polymorphisms (1931T/C and 1951G/A) in the promoter region of the CYP17 gene with breast cancer risk in Japanese women. No significant association was observed between CYP17 polymorphism(1951G/A) and breast cancer risk (odds ratio (OR) = 1.71, 95% confidence interval (CI): 0.28-1.84). In contrast, a significant increase in breast cancer risk (OR= 1.82. 95% CI: 1.07-3.12) was observed in CYP17(1931C/C) homozygotes compared with CYP17(1931T/C) heterozygotes and CYP17(1931T/T) homozygotes when women aged > or = 55 years were considered, but such a significant increase was not observed when women aged < or = 54 years were considered (OR = 0.96, 95% CI: 0.56-1.63). These results suggest that CYP17 polymorphism(1931T/C) would be useful in the selection of Japanese women at a high risk for developing breast cancer at the age of > or = 55 years.

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Year:  2000        PMID： 11094312     DOI： 10.1016/s0959-8049(00)00334-8

Source DB:  PubMed          Journal:  Eur J Cancer        ISSN： 0959-8049            Impact factor:   9.162


  11 in total

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2.  Polymorphisms in steroid hormone biosynthesis genes and risk of breast cancer and fibrocystic breast conditions in Chinese women.

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3.  Estrogen and progesterone-related gene variants and colorectal cancer risk in women.

Authors:  Jennifer H Lin; JoAnn E Manson; Peter Kraft; Barbara B Cochrane; Marc J Gunter; Rowan T Chlebowski; Shumin M Zhang
Journal:  BMC Med Genet       Date:  2011-05-31       Impact factor: 2.103

4.  CYP17 and breast cancer: no overall effect, but what about interactions?

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Journal:  Breast Cancer Res       Date:  2005-09-20       Impact factor: 6.466

5.  CYP17 gene polymorphism in relation to breast cancer risk: a case-control study.

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Journal:  Breast Cancer Res       Date:  2005-09-14       Impact factor: 6.466

6.  CYP17 5'-UTR MspA1 polymorphism and the risk of premenopausal breast cancer in a German population-based case-control study.

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7.  CYP17 genetic polymorphism, breast cancer, and breast cancer risk factors: Australian Breast Cancer Family Study.

Authors:  Jiun-Horng Chang; Dorota M Gertig; Xiaoqing Chen; Gillian S Dite; Mark A Jenkins; Roger L Milne; Melissa C Southey; Margaret R E McCredie; Graham G Giles; Georgia Chenevix-Trench; John L Hopper; Amanda B Spurdle
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8.  Variants in estrogen-biosynthesis genes CYP17 and CYP19 and breast cancer risk: a family-based genetic association study.

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Journal:  Breast Cancer Res       Date:  2004-11-11       Impact factor: 6.466

9.  CYP17 genetic polymorphism, breast cancer, and breast cancer risk factors.

Authors:  Christine B Ambrosone; Kirsten B Moysich; Helena Furberg; Jo L Freudenheim; Elise D Bowman; Sabrina Ahmed; Saxon Graham; John E Vena; Peter G Shields
Journal:  Breast Cancer Res       Date:  2003-01-29       Impact factor: 6.466

Review 10.  The role of polymorphism in various potential genes on polycystic ovary syndrome susceptibility and pathogenesis.

Authors:  Hiral Chaudhary; Jalpa Patel; Nayan K Jain; Rushikesh Joshi
Journal:  J Ovarian Res       Date:  2021-09-26       Impact factor: 4.234
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