Literature DB >> 11094257

Hijacking a chaperone: manipulation of the MHC class II presentation pathway.

N Koch1, I R van Driel, P A Gleeson.   

Abstract

Novel antigen delivery systems are currently being developed by genetic manipulation of the MHC class II trafficking pathway. Specific targeting of endogenously synthesized antigens to the class II loading compartment can result in massively enhanced presentation of peptide epitopes. This emerging technology holds promise for a variety of clinical applications including vaccine development, cancer therapies and control of autoimmune diseases.

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Year:  2000        PMID： 11094257     DOI： 10.1016/s0167-5699(00)01717-5

Source DB:  PubMed          Journal:  Immunol Today        ISSN： 0167-5699


  4 in total

1.  Tolerance induction using lentiviral gene delivery delays onset and severity of collagen II arthritis.

Authors:  Inger Gjertsson; Karen L Laurie; James Devitt; Steven J Howe; Adrian J Thrasher; Rikard Holmdahl; Kenth Gustafsson
Journal:  Mol Ther       Date:  2009-01-27       Impact factor: 11.454

2.  alpha-Tocopheryl succinate promotes selective cell death induced by vitamin K3 in combination with ascorbate.

Authors:  M Tomasetti; E Strafella; S Staffolani; L Santarelli; J Neuzil; R Guerrieri
Journal:  Br J Cancer       Date:  2010-03-23       Impact factor: 7.640

3.  Modulation of immune responses to bovine herpesvirus-1 in cattle by immunization with a DNA vaccine encoding glycoprotein D as a fusion protein with bovine CD154.

Authors:  Sharmila Manoj; Philip J Griebel; Lorne A Babiuk; Sylvia van Drunen Littel-van den Hurk
Journal:  Immunology       Date:  2004-06       Impact factor: 7.397

4.  A novel family of human leukocyte antigen class II receptors may have its origin in archaic human species.

Authors:  Sebastian Temme; Martin Zacharias; Jürgen Neumann; Sebastian Wohlfromm; Angelika König; Nadine Temme; Sebastian Springer; John Trowsdale; Norbert Koch
Journal:  J Biol Chem       Date:  2013-11-08       Impact factor: 5.157
  4 in total

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