P Teale1, M Reite, D C Rojas, J Sheeder, D Arciniegas. 1. Biomagnetic Imaging Laboratory, Department of Psychiatry, University of Colorado Health Sciences Center, and Denver VA Medical Center, Denver, Colorado, USA.
Abstract
BACKGROUND: Several studies have demonstrated anomalous asymmetry of the 100-msec latency auditory-evoked field (M100) in schizophrenia. Recent evidence suggests this may be a compound component, however. Our study examines the localization of two M100 subcomponents in patients with schizophrenia and schizoaffective disorder. METHODS: Magnetoencephalographic recordings of auditory-evoked fields were obtained for 14 subjects with schizophrenia, 12 with schizoaffective disorder, and 23 control subjects. Two M100 subcomponents were identified and localized in each hemisphere. RESULTS: Both patient groups exhibited different lateralization compared with control subjects, with the second subcomponent tending to be less lateralized. CONCLUSIONS: The second subcomponent may be the major contributor to previously reported laterality differences. Future studies might benefit by separating M100 subcomponents so that specific functions could be addressed.
BACKGROUND: Several studies have demonstrated anomalous asymmetry of the 100-msec latency auditory-evoked field (M100) in schizophrenia. Recent evidence suggests this may be a compound component, however. Our study examines the localization of two M100 subcomponents in patients with schizophrenia and schizoaffective disorder. METHODS: Magnetoencephalographic recordings of auditory-evoked fields were obtained for 14 subjects with schizophrenia, 12 with schizoaffective disorder, and 23 control subjects. Two M100 subcomponents were identified and localized in each hemisphere. RESULTS: Both patient groups exhibited different lateralization compared with control subjects, with the second subcomponent tending to be less lateralized. CONCLUSIONS: The second subcomponent may be the major contributor to previously reported laterality differences. Future studies might benefit by separating M100 subcomponents so that specific functions could be addressed.
Authors: Tony W Wilson; Donald C Rojas; Peter D Teale; Olivia O Hernandez; Ryan M Asherin; Martin L Reite Journal: Psychiatry Res Date: 2007-08-28 Impact factor: 3.222
Authors: Timothy P L Roberts; Gwen L Schmidt; Marc Egeth; Lisa Blaskey; Michael M Rey; J Christopher Edgar; Susan E Levy Journal: Int J Psychophysiol Date: 2008-02-12 Impact factor: 2.997
Authors: Martin Reite; Peter Teale; Donald C Rojas; Erik Reite; Ryan Asherin; Olivia Hernandez Journal: Bipolar Disord Date: 2009-06 Impact factor: 6.744