Literature DB >> 11093718

Synthesis of galactosyl and lactosyl derivatives as potential anti-metastasis compounds.

H Li1, Q Li, M S Cai, Z J Li.   

Abstract

Based on the known anti-metastasis activities of lactosides and galactosides, a galactosyl and a lactosyl trimannoside were prepared via the conventional Koenigs-Knorr and trichloroacetimidate methods, respectively. Through typical deblocking procedures, a tetrasaccharide alpha-D-Galp-(1 --> 2)-alpha-D-Manp-(1 --> 2)-alpha-D-Manp-(1 --> 6)-alpha-D-ManpOCH3 and a pentasaccharide beta-D-Galp-(1 --> 4)-beta-D-Glcp-(1 --> 2)-alpha-D-Manp-(1 --> 2)-alpha-D-Manp-(1 --> 6)-alpha-D-ManpOCH3 were obtained.

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Year:  2000        PMID： 11093718     DOI： 10.1016/s0008-6215(00)00137-3

Source DB:  PubMed          Journal:  Carbohydr Res        ISSN： 0008-6215            Impact factor:   2.104


  4 in total

1.  Therapeutic effects of lactosyl derivative Gu-4 in a collagen-induced arthritis rat model.

Authors:  Jie Fan; Huiting Zhou; Shihui Wang; Hailian Wang; Yushun Zhang; Yingtao Guo; Qing Li; Zhongjun Li; Zhihui Zhao
Journal:  Glycoconj J       Date:  2012-06-12       Impact factor: 2.916

2.  Lactosyl derivatives function in a rat model of severe burn shock by acting as antagonists against CD11b of integrin on leukocytes.

Authors:  Zhihui Zhao; Qing Li; Jiale Hu; Zhongjun Li; Jinghua Liu; Aihua Liu; Peng Deng; Lin Zhang; Xiaowei Gong; Kesen Zhao; Shuangquan Zhang; Yong Jiang
Journal:  Glycoconj J       Date:  2008-11-20       Impact factor: 2.916

3.  Impact of the nature and size of the polymeric backbone on the ability of heterobifunctional ligands to mediate shiga toxin and serum amyloid p component ternary complex formation.

Authors:  Pavel I Kitov; Eugenia Paszkiewicz; Joanna M Sadowska; Zhicheng Deng; Marya Ahmed; Ravin Narain; Thomas P Griener; George L Mulvey; Glen D Armstrong; David R Bundle
Journal:  Toxins (Basel)       Date:  2011-08-25       Impact factor: 4.546

4.  A dual-role of Gu-4 in suppressing HMGB1 secretion and blocking HMGB1 pro-inflammatory activity during inflammation.

Authors:  Huiting Zhou; Xuemei Ji; Yun Wu; Ju Xuan; Zhilin Qi; Lei Shen; Lei Lan; Qing Li; Zhimin Yin; Zhongjun Li; Zhihui Zhao
Journal:  PLoS One       Date:  2014-03-06       Impact factor: 3.240
  4 in total

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