Literature DB >> 11092842

Complex trait analysis in the mouse: The strengths, the limitations and the promise yet to come.

K J Moore1, D L Nagle.   

Abstract

In 1990, David Baltimore predicted that the 1990s would be the decade of the mouse (). This certainly proved to be true: The mouse has contributed immensely to biological research through transgenic, embryonic stem cell (ES) knockout, and classical genetic technologies. But its usefulness as a model organism is by no means over; indeed it is still rising to its peak: The mouse as a model mammalian organism still has much to offer. This article reviews use of the mouse to dissect complex genetic traits using quantitative trait analysis, with a particular emphasis on medically important diseases.

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Year:  2000        PMID： 11092842     DOI： 10.1146/annurev.genet.34.1.653

Source DB:  PubMed          Journal:  Annu Rev Genet        ISSN： 0066-4197            Impact factor:   16.830


  32 in total

1.  Identification of wound healing/regeneration quantitative trait loci (QTL) at multiple time points that explain seventy percent of variance in (MRL/MpJ and SJL/J) mice F2 population.

Authors:  G L Masinde; X Li; W Gu; H Davidson; S Mohan; D J Baylink
Journal:  Genome Res       Date:  2001-12       Impact factor: 9.043

2.  A large-sample QTL study in mice: I. Growth.

Authors:  Joao L Rocha; Eugene J Eisen; L Dale Van Vleck; Daniel Pomp
Journal:  Mamm Genome       Date:  2004-02       Impact factor: 2.957

Review 3.  The relevance of individual genetic background and its role in animal models of epilepsy.

Authors:  P Elyse Schauwecker
Journal:  Epilepsy Res       Date:  2011-10-15       Impact factor: 3.045

4.  Quantitative trait loci for baseline white blood cell count, platelet count, and mean platelet volume.

Authors:  Luanne L Peters; Weidong Zhang; Amy J Lambert; Carlo Brugnara; Gary A Churchill; Orah S Platt
Journal:  Mamm Genome       Date:  2005-10-29       Impact factor: 2.957

5.  A large-sample QTL study in mice: III. Reproduction.

Authors:  Joao L Rocha; Eugene J Eisen; Frank Siewerdt; L Dale Van Vleck; Daniel Pomp
Journal:  Mamm Genome       Date:  2004-11       Impact factor: 2.957

6.  Establishment of consomic strains derived from A/J and SM/J mice for genetic analysis of complex traits.

Authors:  Tamio Ohno; Keiko Hata; Taisuke Baba; Fusayo Io; Misato Kobayashi; Fumihiko Horio; Masahiko Nishimura
Journal:  Mamm Genome       Date:  2012-10-10       Impact factor: 2.957

Review 7.  Genetic animal models of anxiety.

Authors:  Deborah A Finn; Mark T Rutledge-Gorman; John C Crabbe
Journal:  Neurogenetics       Date:  2003-03-29       Impact factor: 2.660

8.  Single and interacting QTLs for cholesterol gallstones revealed in an intercross between mouse strains NZB and SM.

Authors:  Malcolm A Lyons; Ron Korstanje; Renhua Li; Susan M Sheehan; Kenneth A Walsh; Jarod A Rollins; Martin C Carey; Beverly Paigen; Gary A Churchill
Journal:  Mamm Genome       Date:  2005-03       Impact factor: 2.957

9.  Transforming growth factor-beta2 is involved in quantitative genetic variation in thymic involution.

Authors:  Ritu Kumar; Jessica C Langer; Hans-Willem Snoeck
Journal:  Blood       Date:  2005-11-10       Impact factor: 22.113

10.  High resolution mapping of trypanosomosis resistance loci Tir2 and Tir3 using F12 advanced intercross lines with major locus Tir1 fixed for the susceptible allele.

Authors:  Joseph K Nganga; Morris Soller; Fuad A Iraqi
Journal:  BMC Genomics       Date:  2010-06-22       Impact factor: 3.969
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