BACKGROUND: Abnormal glycosylation patterns have been recognized as a featureof carcinomaassociated mucins. The expression of the Tn antigen in breast cancer tissue was investigated to assess its prognostic relevance. METHODS: Formalin-fixed, paraffin-embedded materials from 219 patients with breast cancer were used. Immunohistochemical staining of the Tn antigen was retrospectively investigated and a lesion staining 10% or more was considered positive RESULTS: Tn antigen expression was present in 99 (45%) of 219 lesions. There were no correlations between Tn antigen expression and mean patient age, nodal status, estrogen receptor status, or menopausal status, but there was a slightly significant association between Tn and tumor size. Patients negative for the Tn antigen had a significantly better survival rate than those who were positive. Multivariate analysis also indicated that Tn expression correlated significantly with overall survival in addition to nodal status and tumor size. CONCLUSION: Tn expression was a significant prognostic factor in breast cancer, but the significance was lost on multivariate analysis. The biological implication of Tn expression in breast cancer needs further investigation.
BACKGROUND: Abnormal glycosylation patterns have been recognized as a featureof carcinomaassociated mucins. The expression of the Tn antigen in breast cancer tissue was investigated to assess its prognostic relevance. METHODS:Formalin-fixed, paraffin-embedded materials from 219 patients with breast cancer were used. Immunohistochemical staining of the Tn antigen was retrospectively investigated and a lesion staining 10% or more was considered positive RESULTS: Tn antigen expression was present in 99 (45%) of 219 lesions. There were no correlations between Tn antigen expression and mean patient age, nodal status, estrogen receptor status, or menopausal status, but there was a slightly significant association between Tn and tumor size. Patients negative for the Tn antigen had a significantly better survival rate than those who were positive. Multivariate analysis also indicated that Tn expression correlated significantly with overall survival in addition to nodal status and tumor size. CONCLUSION: Tn expression was a significant prognostic factor in breast cancer, but the significance was lost on multivariate analysis. The biological implication of Tn expression in breast cancer needs further investigation.
Authors: Sandra O Demichelis; Marina T Isla-Larrain; Luciano Cermignani; Cecilio G Alberdi; Amada Segal-Eiras; María Virginia Croce Journal: Breast Cancer (Dove Med Press) Date: 2011-12-20
Authors: Tongzhong Ju; Rajindra P Aryal; Matthew R Kudelka; Yingchun Wang; Richard D Cummings Journal: Cancer Biomark Date: 2014-01-01 Impact factor: 4.388
Authors: Bianca T Hofmann; Laura Schlüter; Philip Lange; Baris Mercanoglu; Florian Ewald; Aljonna Fölster; Aeint-Steffen Picksak; Sönke Harder; Alexander T El Gammal; Katharina Grupp; Cenap Güngör; Astrid Drenckhan; Hartmut Schlüter; Christoph Wagener; Jakob R Izbicki; Manfred Jücker; Maximilian Bockhorn; Gerrit Wolters-Eisfeld Journal: Mol Cancer Date: 2015-05-29 Impact factor: 27.401