Literature DB >> 11091549

Adhesion of Human Breast Cancer Cells to Vascular Endothelium Mediated by Sialyl Lewis &supx; /E-selectin.

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Abstract

The adhesion molecules involved in the attachment of breast cancer cells to endothelial cells were investigated in vitro. All six human breast cancer cell lines expressed sialyl Lewis &supx; antigen(s-Le &supx;). Only two cell lines expressed sialyl Lewis&supa; antigen. A correlation was found between the degree of s-Le&supx; expression and the attachment of cancer cells to human umbilical vein endothelial cells (HUVECs) activated by IL-1beta. Monoclonal antibodies against s-Le &supx; or E-selectin inhibited this adhesion. These findings suggest that s-Le &supx; on the surface of cancer cells and E-selectin on the surface of endothelial cells play roles in adheision of breast cancer cells to vascular endothelium.

Entities:  

Year:  1996        PMID： 11091549     DOI： 10.1007/BF02966958

Source DB:  PubMed          Journal:  Breast Cancer        ISSN： 1340-6868            Impact factor:   4.239


  8 in total

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Authors:  G V Glinsky
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3.  Adhesion of human cancer cells to vascular endothelium mediated by a carbohydrate antigen, sialyl Lewis A.

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5.  Association of expression of blood group-related carbohydrate antigens with prognosis in breast cancer.

Authors:  T Narita; H Funahashi; Y Satoh; T Watanabe; J Sakamoto; H Takagi
Journal:  Cancer       Date:  1993-05-15       Impact factor: 6.860

6.  Importance of E-selectin (ELAM-1) and sialyl Lewis(a) in the adhesion of pancreatic carcinoma cells to activated endothelium.

Authors:  K Iwai; H Ishikura; M Kaji; H Sugiura; A Ishizu; C Takahashi; H Kato; T Tanabe; T Yoshiki
Journal:  Int J Cancer       Date:  1993-07-30       Impact factor: 7.396

7.  Differential E-selectin-dependent adhesion efficiency in sublines of a human colon cancer exhibiting distinct metastatic potentials.

Authors:  R Sawada; S Tsuboi; M Fukuda
Journal:  J Biol Chem       Date:  1994-01-14       Impact factor: 5.157

8.  Contribution of carbohydrate antigens sialyl Lewis A and sialyl Lewis X to adhesion of human cancer cells to vascular endothelium.

Authors:  A Takada; K Ohmori; T Yoneda; K Tsuyuoka; A Hasegawa; M Kiso; R Kannagi
Journal:  Cancer Res       Date:  1993-01-15       Impact factor: 12.701
  8 in total
  8 in total

1.  The emerging importance of α-L-fucose in human breast cancer: a review.

Authors:  Jay J Listinsky; Gene P Siegal; Catherine M Listinsky
Journal:  Am J Transl Res       Date:  2011-07-20       Impact factor: 4.060

Review 2.  Targeting selectins and selectin ligands in inflammation and cancer.

Authors:  Steven R Barthel; Jacyln D Gavino; Leyla Descheny; Charles J Dimitroff
Journal:  Expert Opin Ther Targets       Date:  2007-11       Impact factor: 6.902

3.  Expression of sialyl-Tn antigen in breast cancer cells transfected with the human CMP-Neu5Ac: GalNAc alpha2,6-sialyltransferase (ST6GalNac I) cDNA.

Authors:  S Julien; M A Krzewinski-Recchi; A Harduin-Lepers; V Gouyer; G Huet; X Le Bourhis; P Delannoy
Journal:  Glycoconj J       Date:  2001 Nov-Dec       Impact factor: 2.916

4.  Expression of E-selectin ligands on circulating tumor cells: cross-regulation with cancer stem cell regulatory pathways?

Authors:  Monica M Burdick; Karissa A Henson; Luis F Delgadillo; Young Eun Choi; Douglas J Goetz; David F J Tees; Fabian Benencia
Journal:  Front Oncol       Date:  2012-08-20       Impact factor: 6.244

5.  Mac-2 binding protein is a novel E-selectin ligand expressed by breast cancer cells.

Authors:  Venktesh S Shirure; Nathan M Reynolds; Monica M Burdick
Journal:  PLoS One       Date:  2012-09-06       Impact factor: 3.240

6.  ESDN inhibits melanoma progression by blocking E-selectin expression in endothelial cells via STAT3.

Authors:  Roberto Coppo; Francesca Orso; Federico Virga; Alberto Dalmasso; Desirée Baruffaldi; Lei Nie; Fabiana Clapero; Daniela Dettori; Lorena Quirico; Elena Grassi; Paola Defilippi; Paolo Provero; Donatella Valdembri; Guido Serini; Mehran M Sadeghi; Massimiliano Mazzone; Daniela Taverna
Journal:  Cancer Lett       Date:  2021-04-13       Impact factor: 9.756

7.  Tumor-associated glycans and their role in gynecological cancers: accelerating translational research by novel high-throughput approaches.

Authors:  Tatiana Pochechueva; Francis Jacob; Andre Fedier; Viola Heinzelmann-Schwarz
Journal:  Metabolites       Date:  2012-11-14

8.  Phenotypic switch in blood: effects of pro-inflammatory cytokines on breast cancer cell aggregation and adhesion.

Authors:  Yue Geng; Siddarth Chandrasekaran; Jong-Wei Hsu; Mishka Gidwani; Andrew D Hughes; Michael R King
Journal:  PLoS One       Date:  2013-01-23       Impact factor: 3.240
  8 in total

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