Literature DB >> 11090957

Neurochemistry and neuropharmacology of emesis - the role of serotonin.

T Endo1, M Minami, M Hirafuji, T Ogawa, K Akita, M Nemoto, H Saito, M Yoshioka, S H Parvez.   

Abstract

Emesis is an instinctive defense reaction caused by the somato-autonomic nerve reflex which is integrated in the medulla oblongata. Emesis caused by cytotoxic drugs and radiation is associated with an increase in the concentration of 5-hydroxytryptamine (5-HT) in the intestinal mucosa and in the brainstem. 5-HT released from enterochromaffin (EC) cells, which synthesize and secrete 5-HT, stimulates the 5-HT(3) receptors on the adjacent vagal afferent nerves. This vagal afferent nerve depolarization may evoke the vomiting reflex. This review describes the role of 5-HT in anticancer drug-induced emesis from the viewpoint of 5-HT release from EC cells and afferent vagus nerve activity.

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Year:  2000        PMID： 11090957     DOI： 10.1016/s0300-483x(00)00314-0

Source DB:  PubMed          Journal:  Toxicology        ISSN： 0300-483X            Impact factor:   4.221


  24 in total

1.  Ultrafast capillary electrophoresis and bioanalytical applications.

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2.  Lifespan Extension in C. elegans Caused by Bacterial Colonization of the Intestine and Subsequent Activation of an Innate Immune Response.

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3.  Palonosetron versus older 5-HT3 receptor antagonists for nausea prevention in patients receiving chemotherapy: a multistudy analysis.

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4.  GDF15 Induces Anorexia through Nausea and Emesis.

Authors:  Tito Borner; Evan D Shaulson; Misgana Y Ghidewon; Amanda B Barnett; Charles C Horn; Robert P Doyle; Harvey J Grill; Matthew R Hayes; Bart C De Jonghe
Journal:  Cell Metab       Date:  2020-01-09       Impact factor: 27.287

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Authors:  Rachel Huddart; Russ B Altman; Teri E Klein
Journal:  Pharmacogenet Genomics       Date:  2019-06       Impact factor: 2.089

6.  A case of pancreatic cancer with severe vomiting treated by endoscopic ultrasound-guided celiac ganglia neurolysis.

Authors:  Asami Kawai; Masataka Kikuyama; Kohei Enokida; Shinya Kawaguchi; Naofumi Shirane; Shuzo Terada
Journal:  Clin J Gastroenterol       Date:  2017-08-16

7.  Peptide YY3-36 and 5-hydroxytryptamine mediate emesis induction by trichothecene deoxynivalenol (vomitoxin).

Authors:  Wenda Wu; Melissa A Bates; Steven J Bursian; Brenna Flannery; Hui-Ren Zhou; Jane E Link; Haibin Zhang; James J Pestka
Journal:  Toxicol Sci       Date:  2013-03-01       Impact factor: 4.849

Review 8.  Chemotherapy-induced nausea and vomiting: optimizing prevention and management.

Authors:  Kamakshi V Rao; Aimee Faso
Journal:  Am Health Drug Benefits       Date:  2012-07

9.  Receptor-selective agonists induce emesis and Fos expression in the brain and enteric nervous system of the least shrew (Cryptotis parva).

Authors:  Andrew P Ray; Seetha Chebolu; Nissar A Darmani
Journal:  Pharmacol Biochem Behav       Date:  2009-08-21       Impact factor: 3.533

10.  Are itch and scratching the nausea and vomiting of skin?

Authors:  Sattar Ostadhadi; Ehsan Azimi; Ethan A Lerner; Ahmad-Reza Dehpour
Journal:  Exp Dermatol       Date:  2016-02-26       Impact factor: 3.960
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