AIMS: To determine whether macrophage migration inhibitory factor (MIF) levels were increased in sera of the patients with iridocyclitis. METHODS: Sera were obtained from 41 patients with acute iridocyclitis, 13 patients with chronic iridocyclitis, and 44 healthy control subjects. MIF levels were determined by a human MIF ELISA. RESULTS: The average levels of MIF in the sera of patients with both acute and chronic iridocyclitis were significantly higher than that of healthy subjects. CONCLUSION: Uveitis induces the elevation of serum MIF, which may affect various inflammatory symptoms in uveitis.
AIMS: To determine whether macrophage migration inhibitory factor (MIF) levels were increased in sera of the patients with iridocyclitis. METHODS: Sera were obtained from 41 patients with acute iridocyclitis, 13 patients with chronic iridocyclitis, and 44 healthy control subjects. MIF levels were determined by a humanMIF ELISA. RESULTS: The average levels of MIF in the sera of patients with both acute and chronic iridocyclitis were significantly higher than that of healthy subjects. CONCLUSION:Uveitis induces the elevation of serum MIF, which may affect various inflammatory symptoms in uveitis.
Authors: N Kitaichi; A Matsuda; S Kotake; K Namba; Y Tagawa; Y Sasamoto; K Ogasawara; K Iwabuchi; K Onoé; H Matsuda; J Nishihira Journal: Curr Eye Res Date: 2000-02 Impact factor: 2.424
Authors: M Bacher; C N Metz; T Calandra; K Mayer; J Chesney; M Lohoff; D Gemsa; T Donnelly; R Bucala Journal: Proc Natl Acad Sci U S A Date: 1996-07-23 Impact factor: 11.205
Authors: A Rothova; H J Buitenhuis; C Meenken; C J Brinkman; A Linssen; C Alberts; L Luyendijk; A Kijlstra Journal: Br J Ophthalmol Date: 1992-03 Impact factor: 4.638
Authors: J Bernhagen; T Calandra; R A Mitchell; S B Martin; K J Tracey; W Voelter; K R Manogue; A Cerami; R Bucala Journal: Nature Date: 1993-10-21 Impact factor: 49.962
Authors: T Calandra; J Bernhagen; C N Metz; L A Spiegel; M Bacher; T Donnelly; A Cerami; R Bucala Journal: Nature Date: 1995-09-07 Impact factor: 49.962