OBJECTIVE: To investigate whether pregnancy accelerates HIV-1 disease progression. METHOD: In two large French SEROCO and SEROGEST prospective cohorts of HIV infected patients, the progression to AIDS in 365 women with a known date of HIV-1 seroconversion was examined by comparing those who delivered after HIV infection (n = 241) with those who did not become pregnant while HIV-infected (n = 124). RESULTS: The crude relative risk of developing AIDS associated with pregnancy was 0.7 [95% confidence interval (CI), 0.4-1.2]. Adjustment for age at seroconversion, the CD4+ cell percentage at entry, and the method used to date seroconversion did not modify the results (adjusted relative risk, 0.7; 95% CI 0.4-1.2). CONCLUSIONS: No deleterious effect of pregnancy on progression from seroconversion to AIDS was found. This result has important implications for the counselling of HIV-infected women of child-bearing age.
OBJECTIVE: To investigate whether pregnancy accelerates HIV-1 disease progression. METHOD: In two large French SEROCO and SEROGEST prospective cohorts of HIV infectedpatients, the progression to AIDS in 365 women with a known date of HIV-1 seroconversion was examined by comparing those who delivered after HIV infection (n = 241) with those who did not become pregnant while HIV-infected (n = 124). RESULTS: The crude relative risk of developing AIDS associated with pregnancy was 0.7 [95% confidence interval (CI), 0.4-1.2]. Adjustment for age at seroconversion, the CD4+ cell percentage at entry, and the method used to date seroconversion did not modify the results (adjusted relative risk, 0.7; 95% CI 0.4-1.2). CONCLUSIONS: No deleterious effect of pregnancy on progression from seroconversion to AIDS was found. This result has important implications for the counselling of HIV-infectedwomen of child-bearing age.
Authors: Valerie Wojna; Richard L Skolasky; Rosa Hechavarría; Rául Mayo; Ola Selnes; Justin C McArthur; Loyda M Meléndez; Elizabeth Maldonado; Carmen D Zorrilla; Hermes García; Edmundo Kraiselburd; Avindra Nath Journal: J Neurovirol Date: 2006-10 Impact factor: 2.643
Authors: V Le Moing; A Taïeb; P Longuet; C Lewden; V Delcey; M C Thiebaut Drobacheff; G Chêne; C Leport Journal: HIV Med Date: 2008-09-14 Impact factor: 3.180
Authors: D Heather Watts; Jeong-Gun Park; Susan E Cohn; Song Yu; Jane Hitti; Alice Stek; Pamela A Clax; Laila Muderspach; Juan J L Lertora Journal: Contraception Date: 2007-12-21 Impact factor: 3.375
Authors: Vlada V Melekhin; Bryan E Shepherd; Samuel E Stinnette; Peter F Rebeiro; Gema Barkanic; Stephen P Raffanti; Timothy R Sterling Journal: PLoS One Date: 2009-09-09 Impact factor: 3.240