Literature DB >> 11087791

Misleading results with the 14-3-3 assay for the diagnosis of Creutzfeldt-Jakob disease.

T Chapman1, D W McKeel, J C Morris.   

Abstract

The definitive diagnosis of Creutzfeldt-Jakob disease (CJD) requires brain tissue analysis. A positive assay for the 14-3-3 protein in CSF has been suggested to be highly sensitive and specific in patients with CJD. The authors describe three patients for whom CSF 14-3-3 assays were falsely positive or falsely negative. Caution against overreliance on this putative biomarker is suggested in the diagnosis of CJD.

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Year:  2000        PMID： 11087791     DOI： 10.1212/wnl.55.9.1396

Source DB:  PubMed          Journal:  Neurology        ISSN： 0028-3878            Impact factor:   9.910


  16 in total

1.  Case 8: absentminded and "walking like a drunk".

Authors:  Matthew A Joenig; Justin McArthur
Journal:  MedGenMed       Date:  2005-02-03

2.  Differential diagnosis of Jakob-Creutzfeldt disease.

Authors:  Ross W Paterson; Charles C Torres-Chae; Amy L Kuo; Tim Ando; Elizabeth A Nguyen; Katherine Wong; Stephen J DeArmond; Aissa Haman; Paul Garcia; David Y Johnson; Bruce L Miller; Michael D Geschwind
Journal:  Arch Neurol       Date:  2012-12

3.  A comparison of tau and 14-3-3 protein in the diagnosis of Creutzfeldt-Jakob disease.

Authors:  Clive Hamlin; Gianfranco Puoti; Sally Berri; Elliott Sting; Carrie Harris; Mark Cohen; Charles Spear; Alberto Bizzi; Sara M Debanne; Douglas Y Rowland
Journal:  Neurology       Date:  2012-07-25       Impact factor: 9.910

4.  CSF Tau proteins reduce misdiagnosis of sporadic Creutzfeldt-Jakob disease suspected cases with inconclusive 14-3-3 result.

Authors:  M J Leitão; I Baldeiras; M R Almeida; M H Ribeiro; A C Santos; M Ribeiro; J Tomás; S Rocha; I Santana; C R Oliveira
Journal:  J Neurol       Date:  2016-06-29       Impact factor: 4.849

5.  A rare case of rapidly progressive dementia with elevated RT-QuIC and negative 14-3-3 and tau proteins.

Authors:  Bhavesh Trikamji; Clive Hamlin; Kelly J Baldwin
Journal:  Prion       Date:  2016-05-03       Impact factor: 3.931

6.  Ethics in prion disease.

Authors:  Kendra Bechtel; Michael D Geschwind
Journal:  Prog Neurobiol       Date:  2013-07-29       Impact factor: 11.685

7.  Voltage-gated potassium channel autoimmunity mimicking creutzfeldt-jakob disease.

Authors:  Michael D Geschwind; K Meng Tan; Vanda A Lennon; Ramon F Barajas; Aissa Haman; Christopher J Klein; S Andrew Josephson; Sean J Pittock
Journal:  Arch Neurol       Date:  2008-10

8.  Severe depression masquerading as Creutzfeldt-Jakob disease.

Authors:  Elizabeth Shiner; Lauren Taylor; Adith Mohan; Shaun Watson; Perminder Singh Sachdev
Journal:  BMJ Case Rep       Date:  2014-04-19

Review 9.  Rapidly progressive dementia.

Authors:  Michael D Geschwind; Aissa Haman; Bruce L Miller
Journal:  Neurol Clin       Date:  2007-08       Impact factor: 3.806

10.  Diagnostic value of CSF protein profile in a Portuguese population of sCJD patients.

Authors:  Inês Esteves Baldeiras; Maria Helena Ribeiro; Paula Pacheco; Alvaro Machado; Isabel Santana; Luís Cunha; Catarina Resende Oliveira
Journal:  J Neurol       Date:  2009-05-06       Impact factor: 4.849
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