Literature DB >> 11086919

A new caffeoyl quinic acid from aster scaber and its inhibitory activity against human immunodeficiency virus-1 (HIV-1) integrase.

H C Kwon1, C M Jung, C G Shin, J K Lee, S U Choi, S Y Kim, K R Lee.   

Abstract

The phytochemical study of the aerial parts of Aster scaber Thunb. (Asteraceae) yielded a new caffeoyl quinic acid, (-) 3,5-dicaffeoyl-muco-quinic acid (2) and three known compounds, (-) 3,5-dicaffeoyl quinic acid (1), (-) 4,5-dicaffeoyl quinic acid (3), (-) 5-caffeoyl quinic acid (4). The structures were established by high resolution spectroscopic methods. The antiviral effects against HIV-1 integrase of the compounds was evaluated. (-) 3,5-Dicaffeoyl-muco-quinic acid (2) exhibited potent antiviral activity with an IC50 value of 7.0 +/- 1.3 microg/ml.

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Year:  2000        PMID： 11086919     DOI： 10.1248/cpb.48.1796

Source DB:  PubMed          Journal:  Chem Pharm Bull (Tokyo)        ISSN： 0009-2363            Impact factor:   1.645


  9 in total

1.  Phytochemical screening, antioxidant, and antimicrobial activities of the crude leaves' extract from Ipomoea batatas (L.) Lam.

Authors:  Márcia Thaís Pochapski; Eliana Cristina Fosquiera; Luís Antônio Esmerino; Elizabete Brasil Dos Santos; Paulo Vitor Farago; Fábio André Santos; Francisco Carlos Groppo
Journal:  Pharmacogn Mag       Date:  2011-04       Impact factor: 1.085

2.  Quinic acid derivatives inhibit dengue virus replication in vitro.

Authors:  Paula Rodrigues Zanello; Andrea Cristine Koishi; Celso de Oliveira Rezende Júnior; Larissa Albuquerque Oliveira; Adriane Antonia Pereira; Mauro Vieira de Almeida; Claudia Nunes Duarte dos Santos; Juliano Bordignon
Journal:  Virol J       Date:  2015-12-22       Impact factor: 4.099

3.  The Effect of Temperature on Pressurised Hot Water Extraction of Pharmacologically Important Metabolites as Analysed by UPLC-qTOF-MS and PCA.

Authors:  B S Khoza; L Chimuka; E Mukwevho; P A Steenkamp; N E Madala
Journal:  Evid Based Complement Alternat Med       Date:  2014-10-13       Impact factor: 2.629

4.  The Effect of Pectinase-Assisted Extraction on the Physicochemical and Biological Properties of Polysaccharides from Aster scaber.

Authors:  Young-Ran Song; Su-Kyung Sung; Eun-Ju Shin; Chang-Won Cho; Chun-Ji Han; Hee-Do Hong
Journal:  Int J Mol Sci       Date:  2018-09-19       Impact factor: 5.923

5.  FT-NIR spectroscopy and RP-HPLC combined with multivariate analysis reveals differences in plant cell suspension cultures of Thevetia peruviana treated with salicylic acid and methyl jasmonate.

Authors:  Dary Mendoza; Juan Pablo Arias; Olmedo Cuaspud; Orlando Ruiz; Mario Arias
Journal:  Biotechnol Rep (Amst)       Date:  2020-08-12

6.  Influence of seasonal and geographic variation on the anti-HSV-1 properties and chlorogenic acids content of Helichrysum aureonitens Sch. Bip.

Authors:  Wilson Bamise Adeosun; Garland K More; Paul Steenkamp; Gerhard Prinsloo
Journal:  Front Mol Biosci       Date:  2022-08-25

7.  The Effect of Geometrical Isomerism of 3,5-Dicaffeoylquinic Acid on Its Binding Affinity to HIV-Integrase Enzyme: A Molecular Docking Study.

Authors:  Mpho M Makola; Ian A Dubery; Gerrit Koorsen; Paul A Steenkamp; Mwadham M Kabanda; Louis L du Preez; Ntakadzeni E Madala
Journal:  Evid Based Complement Alternat Med       Date:  2016-10-18       Impact factor: 2.629

Review 8.  Medicinal Plants Used in the Treatment of Human Immunodeficiency Virus.

Authors:  Bahare Salehi; Nanjangud V Anil Kumar; Bilge Şener; Mehdi Sharifi-Rad; Mehtap Kılıç; Gail B Mahady; Sanja Vlaisavljevic; Marcello Iriti; Farzad Kobarfard; William N Setzer; Seyed Abdulmajid Ayatollahi; Athar Ata; Javad Sharifi-Rad
Journal:  Int J Mol Sci       Date:  2018-05-14       Impact factor: 5.923

9.  GC-MS Phytochemical Profiling, Pharmacological Properties, and In Silico Studies of Chukrasia velutina Leaves: A Novel Source for Bioactive Agents.

Authors:  Israt Jahan; Marzia Rahman Tona; Sanjida Sharmin; Mohammed Aktar Sayeed; Fatamatuz Zuhura Tania; Arkajyoti Paul; Md Nazim Uddin Chy; Ahmed Rakib; Talha Bin Emran; Jesus Simal-Gandara
Journal:  Molecules       Date:  2020-08-02       Impact factor: 4.411
  9 in total

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