| Literature DB >> 11086733 |
J Zhang1, S Didierlaurent, M Fortin, D Lefrançois, E Uridat, J P Vevert.
Abstract
We have previously reported the identification of pyrazole-5-carboxylic acids as a new class of endothelin antagonists from low affinity pyrazol-5-ol ligands, which were obtained by random screening assays. We describe herein the synthesis and the structure activity relationships (SARs) of these pyrazole-5-carboxylic acids with potent ET(A) selective, mixed ET(A)/ET(B) or moderately ET(B) selective antagonist activities.Entities:
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Year: 2000 PMID： 11086733 DOI： 10.1016/s0960-894x(00)00513-8
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823