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Literature DB >> 1108643

Age trends in human chiasma frequencies and recombination fractions. II. Method for analyzing recombination fractions and applications to the ABO:nail-patella linkage.

Abstract

A new method is presented for studying the relationship between human recombination fractions and parental age at the time of conception. Assuming the sex specific recombination fraction to be a linear function of age, a feasible computer algorithm is described whereby the likelihood of multigenerational families can be calculated. Using this method and the likelihood ratio test, it is found that for the ABO:nail-patella linkage age (P= .17)is more significant than sex (p= .23) in its effect on the recombination fraction. The age effect, if it is real, appears to be limited to males: the paternal recombination fraction decreases by .0062(+/- .0036) per year.

Entities: Gene Species

Mesh：

Substances：
ABO Blood-Group System

Year: 1976 PMID： 1108643 PMCID： PMC1684899

Source DB: PubMed Journal: Am J Hum Genet ISSN： 0002-9297 Impact factor: 11.025

15 in total

1. General models for segregation analysis.

Authors: R C Elston; K C Yelverton
Journal: Am J Hum Genet Date: 1975-01 Impact factor: 11.025

2. Genetical linkage between the ABO and nail-patella loci.

Authors: J H RENWICK; S D LAWLER
Journal: Ann Hum Genet Date: 1955-06 Impact factor: 1.670

3. Sex of parent and variation of recombination with age in the mouse.

Authors: D H REID; P A PARSONS
Journal: Heredity (Edinb) Date: 1963-02 Impact factor: 3.821

4. Data on linkage in man. The nail-patella syndrome, family S.

Authors: C A CLARKE; R B McCONNELL; P M SHEPPARD
Journal: Ann Hum Genet Date: 1961-05 Impact factor: 1.670

5. Nail-patella syndrome: clinical and linkage data on family G.

Authors: R J JAMESON; S D LAWLER; J H RENWICK
Journal: Ann Hum Genet Date: 1956-05 Impact factor: 1.670

6. Further families showing linkage between the ABO and nail-patella loci, with no evidence of heterogeneity.

Authors: S D LAWLER; J H RENWICK; L S WILDER-VANCK
Journal: Ann Hum Genet Date: 1957-06 Impact factor: 1.670

7. Linkage tests involving the P blood group locus and further data on the ABO: nail-patella linkage.

Authors: S D LAWLER; J H RENWICK; J MOSBECH; L S WILDERVANCK; M HAUGE
Journal: Ann Hum Genet Date: 1958-07 Impact factor: 1.670

8. The Blood Groups of a Further Family with Nail-Patella Syndrome.

Authors: G B Elliott; M Lewis; H Kaita; B Chown
Journal: Am J Hum Genet Date: 1963-06 Impact factor: 11.025

9. Age trends in human chiasma frequencies and recombination fractions. I. Chiasma frequencies.

Authors: K Lange; B M Page; R C Elston
Journal: Am J Hum Genet Date: 1975-05 Impact factor: 11.025

10. Nail-patella syndrome in an Indian family: clinical and linkage data.

Authors: J C Sharma
Journal: Ann Hum Genet Date: 1966-11 Impact factor: 1.670

7 in total

1. Joint estimation of recombination fractions and interference coefficients in multilocus linkage analysis.

Authors: L P Zhao; E Thompson; R Prentice
Journal: Am J Hum Genet Date: 1990-08 Impact factor: 11.025

2. Single-sperm typing: determination of genetic distance between the G gamma-globin and parathyroid hormone loci by using the polymerase chain reaction and allele-specific oligomers.

Authors: X F Cui; H H Li; T M Goradia; K Lange; H H Kazazian; D Galas; N Arnheim
Journal: Proc Natl Acad Sci U S A Date: 1989-12 Impact factor: 11.205