Invertebrate molecular neuroimmune processes.

During the course of evolution, invertebrates and vertebrates have kept in common similar signaling molecules e.g. neuropeptides, opiates etc... Complete hormonal-enzymatic systems such as the opioid-opiate-cannabinoid systems have been found in both nervous central and immune systems of these animals. These signaling molecules can be found free in blood circulation and act as immunomodulators. The present review is focused on peptides derived from the opioid proopiomelanocortin precursor, the opiates and the endocannabinoids, which are very powerful immunosuppressors, and example models of the bidirectional communications between the endocrine and the immune systems. Parasites use these immunosuppressors with magnificence in their crosstalk with their host.