Literature DB >> 11084689

Regulated cutaneous gene delivery: the skin as a bioreactor.

T Cao1, X J Wang, D R Roop.   

Abstract

Epidermal keratinocytes can secrete polypeptides into the bloodstream, and they can be easily expanded in culture and genetically modified. It is thus possible to use epidermal keratinocytes for the systemic delivery of transgene products. Here we review the development of epidermal secretory systems, from cultured keratinocytes to skin grafts and transgenic mouse models. We also discuss a gene-switch approach for regulated cutaneous gene delivery.

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Year:  2000        PMID： 11084689     DOI： 10.1089/104303400750035843

Source DB:  PubMed          Journal:  Hum Gene Ther        ISSN： 1043-0342            Impact factor:   5.695


  4 in total

Review 1.  High-level secretion of growth hormone by retrovirally transduced primary human keratinocytes: prospects for an animal model of cutaneous gene therapy.

Authors:  Cibele Nunes Peroni; Cláudia Regina Cecchi; Renata Damiani; Carlos R J Soares; Maria Teresa C P Ribela; Rosângela do Rocio Arkaten; Paolo Bartolini
Journal:  Mol Biotechnol       Date:  2006-10       Impact factor: 2.695

2.  Immune-mediated loss of transgene expression in skin: implications for cutaneous gene therapy.

Authors:  Soosan Ghazizadeh; Richard S Kalish; Lorne B Taichman
Journal:  Mol Ther       Date:  2003-03       Impact factor: 11.454

3.  A gene therapy approach for long-term normalization of blood pressure in hypertensive mice by ANP-secreting human skin grafts.

Authors:  Jean-Philippe Therrien; Soo Mi Kim; Atsushi Terunuma; Yan Qin; Christine L Tock; Wolfgang Pfützner; Manabu Ohyama; Jurgen Schnermann; Jonathan C Vogel
Journal:  Proc Natl Acad Sci U S A       Date:  2010-01-11       Impact factor: 11.205

4.  Nucleofection: a new method for cutaneous gene transfer?

Authors:  Frank Jacobsen; Janine Mertens-Rill; Juergen Beller; Tobias Hirsch; Adrien Daigeler; Stefan Langer; Marcus Lehnhardt; Hans-Ulrich Steinau; Lars Steinstraesser
Journal:  J Biomed Biotechnol       Date:  2006
  4 in total

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