Literature DB >> 11082002

A short catalytic enantioselective synthesis of the vascular antiinflammatory eicosanoid (11R,12S)-oxidoarachidonic acid.

X Han1, S N Crane, E J Corey.   

Abstract

[reaction: see text] An effective pathway is described for the synthesis of (11R, 12S)-oxidoarachidonic acid (1) from the achiral precursors shown.

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Year:  2000        PMID： 11082002     DOI： 10.1021/ol006430b

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  2 in total

1.  Asymmetric Total Synthesis of 19,20-Epoxydocosapentaenoic Acid, a Bioactive Metabolite of Docosahexaenoic Acid.

Authors:  Maris A Cinelli; Kin Sing Stephen Lee
Journal:  J Org Chem       Date:  2019-11-21       Impact factor: 4.354

2.  Enzymatic synthesis and chemical inversion provide both enantiomers of bioactive epoxydocosapentaenoic acids.

Authors:  Maris A Cinelli; Jun Yang; Amy Scharmen; Joey Woodman; Lalitha M Karchalla; Kin Sing Stephen Lee
Journal:  J Lipid Res       Date:  2018-09-12       Impact factor: 5.922
  2 in total

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