Literature DB >> 1108194

Microtubule assembly and the intracellular transport of secretory granules in pancreatic islets.

D G Pipeleers, M A Pipeleers-Marichal, D M Kipnis.   

Abstract

Polymerized and depolymerized tubulin were measured in pancreatic islets under various physiological and pharmacological conditions. Variations in insulin release from islets of fed or fasted rats were accompanied by concomitant changes in tubulin polymerization. Glucose induced the formation of microtubules in vitro independent of extracellular calcium. Total and polymerized tubulin content were decreased by fasting and restored by glucose feeding.

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Year:  1976        PMID： 1108194     DOI： 10.1126/science.1108194

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  25 in total

1.  Phosphorylation of pig brain microtubule proteins. General properties and partial characterization of endogenous substrate and cyclic AMP-dependent protein kinase.

Authors:  P Sheterline
Journal:  Biochem J       Date:  1977-12-15       Impact factor: 3.857

2.  Aged insulin granules display reduced microtubule-dependent mobility and are disposed within actin-positive multigranular bodies.

Authors:  Peter Hoboth; Andreas Müller; Anna Ivanova; Hassan Mziaut; Jaber Dehghany; Anke Sönmez; Martina Lachnit; Michael Meyer-Hermann; Yannis Kalaidzidis; Michele Solimena
Journal:  Proc Natl Acad Sci U S A       Date:  2015-02-02       Impact factor: 11.205

3.  Regulation of tubulin synthesis in islets of Langerhans.

Authors:  D G Pipeleers; M A Pipeleers-Marichal; D M Kipnis
Journal:  Proc Natl Acad Sci U S A       Date:  1976-09       Impact factor: 11.205

4.  Immediate and time-dependent effects of glucose on insulin release from rat pancreatic tissue. Evidence for different mechanisms of action.

Authors:  V Grill; U Adamson; E Cerasi
Journal:  J Clin Invest       Date:  1978-04       Impact factor: 14.808

5.  Effects of MBC on hyphal tip organization, growth, and mitosis of Fusarium acuminatum, and their antagonism by D2O.

Authors:  R J Howard; J R Aist
Journal:  Protoplasma       Date:  1977       Impact factor: 3.356

6.  Pedigrees of 30 families with Alzheimer disease: associations with defective organization of microfilaments and microtubules.

Authors:  L L Heston; J White
Journal:  Behav Genet       Date:  1978-07       Impact factor: 2.805

Review 7.  The biosociology of pancreatic B cells.

Authors:  D Pipeleers
Journal:  Diabetologia       Date:  1987-05       Impact factor: 10.122

8.  Role of microtubules in the synthesis, conversion, and release of (pro)insulin. A biochemical and radioautographic study in rat islets.

Authors:  F Malaisse-Lagae; M Amherdt; M Ravazzola; A Sener; J C Hutton; L Orci; W J Malaisse
Journal:  J Clin Invest       Date:  1979-06       Impact factor: 14.808

9.  Glucose-stimulated 45Calcium efflux from isolated rat pancreatic islets.

Authors:  B J Frankel; W T Imagawa; M D O'Connor; I Lundquist; J A Kromhout; R E Fanska; G M Grodsky
Journal:  J Clin Invest       Date:  1978-09       Impact factor: 14.808

10.  The effects of colchicine on the distribution of glycoprotein-containing vesicles in epithelial cells of the murine colon.

Authors:  J E Michaels
Journal:  Cell Tissue Res       Date:  1983       Impact factor: 5.249
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