BACKGROUND: About one-third to one-half of patients with early stages of non-small cell lung cancer (NSCLC) succumb to their disease. In this study, we attempted to identify prognostic factors that predict outcome in patients with stages I and II NSCLC. METHODS: A retrospective evaluation of 454 patients with surgically resected stages I and II NSCLC was performed to determine the impact of various clinical, laboratory, and pathological factors on patient outcome such as overall survival (OS) and event-free survival (EFS). RESULTS: Patients older than 65 years had shorter EFS and OS than younger patients (p = 0.002). Patients with preoperative hemoglobin less than or equal to 10 g% had shorter EFS and OS compared to patients with a hemoglobin greater than 10 g% (p = 0.001). Expectedly, OS and EFS were shorter in patients with stage II as compared to stage I patients (p < 0.001). In a multivariate analysis, age, hemoglobin level, and stage remain significant predictors for EFS and OS. CONCLUSIONS: Older age, anemia, and higher stage are important prognostic factors in patients with surgically resected stage I and II NSCLC.
BACKGROUND: About one-third to one-half of patients with early stages of non-small cell lung cancer (NSCLC) succumb to their disease. In this study, we attempted to identify prognostic factors that predict outcome in patients with stages I and II NSCLC. METHODS: A retrospective evaluation of 454 patients with surgically resected stages I and II NSCLC was performed to determine the impact of various clinical, laboratory, and pathological factors on patient outcome such as overall survival (OS) and event-free survival (EFS). RESULTS:Patients older than 65 years had shorter EFS and OS than younger patients (p = 0.002). Patients with preoperative hemoglobin less than or equal to 10 g% had shorter EFS and OS compared to patients with a hemoglobin greater than 10 g% (p = 0.001). Expectedly, OS and EFS were shorter in patients with stage II as compared to stage I patients (p < 0.001). In a multivariate analysis, age, hemoglobin level, and stage remain significant predictors for EFS and OS. CONCLUSIONS: Older age, anemia, and higher stage are important prognostic factors in patients with surgically resected stage I and II NSCLC.
Authors: M Gierth; R Mayr; A Aziz; S Krieger; B Wullich; A Pycha; M Lodde; U Salvadori; J Bründl; H M Fritsche; F Hofstädter; M T Pawlik; W Otto; M May; M Burger; S Denzinger Journal: J Cancer Res Clin Oncol Date: 2015-04-02 Impact factor: 4.553
Authors: Tina Schubert; Tilman Todenhöfer; Johannes Mischinger; Christian Schwentner; Markus Renninger; Arnulf Stenzl; Georgios Gakis Journal: World J Urol Date: 2015-09-29 Impact factor: 4.226
Authors: Pilar Ma Samper Ots; Concepción López Carrizosa; Aurora Rodríguez Pérez; Juan de Dios Saez Garrido; José Ma Delgado Pérez Journal: Clin Med Oncol Date: 2008-05-19
Authors: Nóris C Scaglia; José M Chatkin; José A Pinto; Maria T R Tsukazan; Mário B Wagner; Adriana F Saldanha Journal: Ann Thorac Med Date: 2013-07 Impact factor: 2.219