Effects of allogenic and effector cells on the development of antibody-producing cells, in vitro.

Effects of allogenic and effector spleen cells on the development of anti-SRBC plaque-forming cells from target spleen cells in vitro were studied. Addition of allogeneic cells resulted in various degrees of suppression of target cell PFC production. This allogeneic suppression could be abolished by pretreating the cells with either uv or X irradiation. Addition of effector cells to target spleen cell cultures markedly suppressed PFC production. Effector cell suppression of PFC production was anti-BAtheta serum-sensitive and radiation-resistant.