Literature DB >> 11080040

Mechanisms of DNA damage by leinamycin.

K S Gates1.   

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Year:  2000        PMID: 11080040     DOI: 10.1021/tx000089m

Source DB:  PubMed          Journal:  Chem Res Toxicol        ISSN: 0893-228X            Impact factor:   3.739


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  17 in total

1.  Noncovalent DNA binding drives DNA alkylation by leinamycin: evidence that the Z,E-5-(thiazol-4-yl)-penta-2,4-dienone moiety of the natural product serves as an atypical DNA intercalator.

Authors:  Mostafa I Fekry; Jozsef Szekely; Sanjay Dutta; Leonid Breydo; Hong Zang; Kent S Gates
Journal:  J Am Chem Soc       Date:  2011-10-18       Impact factor: 15.419

Review 2.  Heteroatom-Heteroatom Bond Formation in Natural Product Biosynthesis.

Authors:  Abraham J Waldman; Tai L Ng; Peng Wang; Emily P Balskus
Journal:  Chem Rev       Date:  2017-04-04       Impact factor: 60.622

3.  Synthesis and characterization of a small analogue of the anticancer natural product leinamycin.

Authors:  Kripa Keerthi; Anuruddha Rajapakse; Daekyu Sun; Kent S Gates
Journal:  Bioorg Med Chem       Date:  2012-10-27       Impact factor: 3.641

4.  Characterization of LnmO as a pathway-specific Crp/Fnr-type positive regulator for leinamycin biosynthesis in Streptomyces atroolivaceus and its application for titer improvement.

Authors:  Yong Huang; Dong Yang; Guohui Pan; Gong-Li Tang; Ben Shen
Journal:  Appl Microbiol Biotechnol       Date:  2016-10-05       Impact factor: 4.813

Review 5.  Persulfides: current knowledge and challenges in chemistry and chemical biology.

Authors:  Chung-Min Park; Laksiri Weerasinghe; Jacob J Day; Jon M Fukuto; Ming Xian
Journal:  Mol Biosyst       Date:  2015-07

6.  Entering the leinamycin rearrangement via 2-(trimethylsilyl)ethyl sulfoxides.

Authors:  Kripa Keerthi; Kent S Gates
Journal:  Org Biomol Chem       Date:  2007-04-13       Impact factor: 3.876

7.  P450-Catalyzed Tailoring Steps in Leinamycin Biosynthesis Featuring Regio- and Stereoselective Hydroxylations and Substrate Promiscuities.

Authors:  Thomas Kwong; Ming Ma; Guohui Pan; Dong Yang; Chunying Yang; Jeremy R Lohman; Jeffrey D Rudolf; John L Cleveland; Ben Shen
Journal:  Biochemistry       Date:  2018-08-02       Impact factor: 3.162

8.  Characterization of DNA damage induced by a natural product antitumor antibiotic leinamycin in human cancer cells.

Authors:  Velliyur Viswesh; Kent Gates; Daekyu Sun
Journal:  Chem Res Toxicol       Date:  2010-01       Impact factor: 3.739

9.  Identification and localization of the gene cluster encoding biosynthesis of the antitumor macrolactam leinamycin in Streptomyces atroolivaceus S-140.

Authors:  Yi-Qiang Cheng; Gong-Li Tang; Ben Shen
Journal:  J Bacteriol       Date:  2002-12       Impact factor: 3.490

10.  Possible chemical mechanisms underlying the antitumor activity of S-deoxyleinamycin.

Authors:  Santhosh Sivaramakrishnan; Kent S Gates
Journal:  Bioorg Med Chem Lett       Date:  2007-11-28       Impact factor: 2.823

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