| Literature DB >> 11079800 |
Y Masuoka1, K Shin-Ya, Y B Kim, M Yoshida, K Nagai, K Suzuki, Y Hayakawa, H Seto.
Abstract
A new metabolite, diheteropeptin, was found in the culture broth of Diheterospora chlamydosporia Q58044 by screening for TGF-beta-like active substances. Diheteropeptin was extracted from the culture supernatant and purified by a series of chromatographies such as silica gel, gel filtration and HPLC. Diheteropeptin exhibited cytostatic activity in Mv1Lu cells with an IC50 value of 20.3 microM and inhibited histone deacetylase.Entities:
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Year: 2000 PMID： 11079800 DOI： 10.7164/antibiotics.53.788
Source DB: PubMed Journal: J Antibiot (Tokyo) ISSN： 0021-8820 Impact factor: 2.649