Literature DB >> 11078909

The p21(cip1/waf1) cyclin-dependent kinase inhibitor enhances the cytotoxic effect of cisplatin in human ovarian carcinoma cells.

H Lincet1, L Poulain, J S Remy, E Deslandes, F Duigou, P Gauduchon, C Staedel.   

Abstract

The seriousness of ovarian cancer, which is related to the observed link between recurrency and cell cycle control defect, prompted us to explore the effect of ectopic expression of the cdk inhibitor p21(cip1/waf1) on ovarian carcinoma chemosensitivity. The transfection of p21(cip1/waf1) cDNA into SKOV3 and OVCAR3 cells led to reduction of tumor cell growth, enhanced susceptibility to cisplatin-induced apoptosis, and abolition of recurrency after cisplatin exposure. p21(cip1/waf1) gene transfer allowed a marked reduction of the cisplatin concentration needed to erradicate the tumor cell population. These results suggest exploring the possible use of p21(cip1/waf1) as an adjunctive to conventional chemotherapy.

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Year:  2000        PMID： 11078909     DOI： 10.1016/s0304-3835(00)00586-3

Source DB:  PubMed          Journal:  Cancer Lett        ISSN： 0304-3835            Impact factor:   8.679


  35 in total

1.  Glutathione content is correlated with the sensitivity of lines of PC12 cells to cisplatin without a corresponding change in the accumulation of platinum.

Authors:  K Ikeda; K Miura; S Himeno; N Imura; A Naganuma
Journal:  Mol Cell Biochem       Date:  2001-03       Impact factor: 3.396

2.  Alterations in nuclear pore architecture allow cancer cell entry into or exit from drug-resistant dormancy.

Authors:  Yayoi Kinoshita; Tamara Kalir; Jamal Rahaman; Peter Dottino; D Stave Kohtz
Journal:  Am J Pathol       Date:  2011-11-07       Impact factor: 4.307

3.  Activation of p21-Dependent G1/G2 Arrest in the Absence of DNA Damage as an Antiapoptotic Response to Metabolic Stress.

Authors:  L Alexis Hoeferlin; Natalia V Oleinik; Natalia I Krupenko; Sergey A Krupenko
Journal:  Genes Cancer       Date:  2011-09

4.  Overexpression of p18INK⁴C in LLC-PK1 cells increases resistance to cisplatin-induced apoptosis.

Authors:  Yi Zhang; Li Yuan; Lili Fu; Chunyan Liu; Dongmei Liu; Changlin Mei
Journal:  Pediatr Nephrol       Date:  2011-04-15       Impact factor: 3.714

5.  An Elk transcription factor is required for Runx-dependent survival signaling in the sea urchin embryo.

Authors:  Francesca Rizzo; James A Coffman; Maria Ina Arnone
Journal:  Dev Biol       Date:  2016-05-24       Impact factor: 3.582

6.  Status of p53 phosphorylation and function in sensitive and resistant human cancer models exposed to platinum-based DNA damaging agents.

Authors:  Kalpana Mujoo; Masayuki Watanabe; Junichi Nakamura; Abdul R Khokhar; Zahid H Siddik
Journal:  J Cancer Res Clin Oncol       Date:  2003-09-26       Impact factor: 4.553

7.  Targeted p21WAF1/CIP1 activation by RNAa inhibits hepatocellular carcinoma cells.

Authors:  Mika Kosaka; Moo Rim Kang; Glen Yang; Long-Cheng Li
Journal:  Nucleic Acid Ther       Date:  2012-08-21       Impact factor: 5.486

Review 8.  Oncogenic role of p21 in hepatocarcinogenesis suggests a new treatment strategy.

Authors:  Shogo Ohkoshi; Masahiko Yano; Yasunobu Matsuda
Journal:  World J Gastroenterol       Date:  2015-11-14       Impact factor: 5.742

9.  Loss of p21Waf1/Cip1/Sdi1 enhances intestinal stem cell survival following radiation injury.

Authors:  Robert J George; Mark A Sturmoski; Randal May; Sripathi M Sureban; Brian K Dieckgraefe; Shrikant Anant; Courtney W Houchen
Journal:  Am J Physiol Gastrointest Liver Physiol       Date:  2008-12-04       Impact factor: 4.052

10.  Elucidation of the molecular mechanisms of a salicylhydrazide class of compounds by proteomic analysis.

Authors:  Xuefei Cao; Carmen Plasencia; Atsuko Kanzaki; Austin Yang; Terrence R Burke; Nouri Neamati
Journal:  Curr Cancer Drug Targets       Date:  2009-03       Impact factor: 3.428
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