Literature DB >> 11078339

Endothelin receptor expression in colorectal cancer.

H Ali1, M Dashwood, K Dawas, M Loizidou, F Savage, I Taylor.   

Abstract

The distribution of endothelin-A- and B- (ET(A), ET(B)) receptor subtypes was compared in colorectal cancer to that in normal colon and their expression in the colorectal cancer cell lines LIM1215. HT29, SKCO1, SKCO17 and LoVo was determined, using gross and high resolution autoradiography and quantified by densitometry. ET(A) and ET(B) binding sites were expressed by all the cell lines. There was significantly (p = 0.008) higher expression of ET(A)-receptors by cancers (205.95 dpm x 1000/mm2) compared normal colon (129.19 dpm x 1000/mm2). However, for ET(B)-receptors, this was reversed, with significantly (p = 0.008) higher expression of ET(B) binding in normal colon (207.00 dpm x 1000/mm2) than in tumours (122.35 dpm x 1000/mm2).

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Year:  2000        PMID： 11078339     DOI： 10.1097/00005344-200036051-00023

Source DB:  PubMed          Journal:  J Cardiovasc Pharmacol        ISSN： 0160-2446            Impact factor:   3.105


  10 in total

Review 1.  Endothelin B receptor, a new target in cancer immune therapy.

Authors:  Lana E Kandalaft; Andrea Facciabene; Ron J Buckanovich; George Coukos
Journal:  Clin Cancer Res       Date:  2009-06-30       Impact factor: 12.531

2.  Endothelin Promotes Colorectal Tumorigenesis by Activating YAP/TAZ.

Authors:  Zhen Wang; Peng Liu; Xin Zhou; Tianxiang Wang; Xu Feng; Yi-Ping Sun; Yue Xiong; Hai-Xin Yuan; Kun-Liang Guan
Journal:  Cancer Res       Date:  2017-03-01       Impact factor: 12.701

Review 3.  Endothelin and hepatic wound healing.

Authors:  Al-karim Khimji; Don C Rockey
Journal:  Pharmacol Res       Date:  2011-03-21       Impact factor: 7.658

4.  The endothelin system in Morris hepatoma-7777: an endothelin receptor antagonist inhibits growth in vitro and in vivo.

Authors:  Thiemo Pfab; Gisela Stoltenburg-Didinger; Christoph Trautner; Michael Godes; Christian Bauer; Berthold Hocher
Journal:  Br J Pharmacol       Date:  2003-12-08       Impact factor: 8.739

5.  Stromal endothelin B receptor-deficiency inhibits breast cancer growth and metastasis.

Authors:  Claudia Binder; Thorsten Hagemann; Swetlana Sperling; Matthias Schulz; Tobias Pukrop; Matthew J Grimshaw; Hannelore Ehrenreich
Journal:  Mol Cancer Ther       Date:  2009-08-11       Impact factor: 6.261

Review 6.  Endothelin-1: a multifunctional molecule in cancer.

Authors:  K Grant; M Loizidou; I Taylor
Journal:  Br J Cancer       Date:  2003-01-27       Impact factor: 7.640

7.  Increased endothelin-1 in colorectal cancer and reduction of tumour growth by ET(A) receptor antagonism.

Authors:  E Asham; A Shankar; M Loizidou; S Fredericks; K Miller; P B Boulos; G Burnstock; I Taylor
Journal:  Br J Cancer       Date:  2001-11-30       Impact factor: 7.640

8.  Blocking endothelin-1-receptor/β-catenin circuit sensitizes to chemotherapy in colorectal cancer.

Authors:  Roberta Cianfrocca; Laura Rosanò; Piera Tocci; Rosanna Sestito; Valentina Caprara; Valeriana Di Castro; Ruggero De Maria; Anna Bagnato
Journal:  Cell Death Differ       Date:  2017-07-14       Impact factor: 15.828

9.  Expression of endothelin-A-receptor predicts unfavourable response to neoadjuvant chemotherapy in locally advanced breast cancer.

Authors:  P Wülfing; J Tio; C Kersting; B Sonntag; H Buerger; C Wülfing; U Euler; W Boecker; A H Tulusan; L Kiesel
Journal:  Br J Cancer       Date:  2004-08-02       Impact factor: 7.640

10.  Enhanced expressions of endothelin-converting enzyme and endothelin receptors in human colonic tissues of Crohn's disease.

Authors:  Takehisa Suekane; Yoshihiro Ikura; Junko Arimoto; Masashi Nakagawa; Chizuko Kitabayashi; Takahiko Naruko; Toshio Watanabe; Yasuhiro Fujiwara; Nobuhide Oshitani; Kiyoshi Maeda; Kazuhiko Tanzawa; Kosei Hirakawa; Tetsuo Arakawa; Makiko Ueda
Journal:  J Clin Biochem Nutr       Date:  2008-03       Impact factor: 3.114
  10 in total

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