Literature DB >> 1107804

Manganese mutagenesis in yeast. IV. The effects of magnesium, protein synthesis inhibitors and hydroxyurea on AntR induction in mitochondrial DNA.

A Putrament, H Baranowska, A Ejchart, W Prazmo.   

Abstract

The induction of antibiotic-resistant mutations in yeast mitochondrial DNA by manganese is decreased when the manganese-containing medium is additionally supplemented with magnesium. At equimolar concentrations of manganese and magnesium the former is no longer mutagenic. Amino acid starvation, cycloheximide, chloramphenicol and erythromycin have very little, if any, effect on the mutagenicity of manganese. Hydroxyurea itself seems to be slightly mutagenicity of manganese. Our results show that manganese acts as an error-producing factor in DNA replication probably through a direct interaction with mitDNA polymerase(s).

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Year:  1975        PMID： 1107804

Source DB:  PubMed          Journal:  Mol Gen Genet        ISSN： 0026-8925


  22 in total

1.  Phospholipids of Escherichia coli in magnesium deficiency.

Authors:  T Günther; L Richter; J Schmalbeck
Journal:  J Gen Microbiol       Date:  1975-01

2.  Recovery of yeast from transient inhibition of DNA synthesis.

Authors:  M L Slater
Journal:  Nature       Date:  1974-02-01       Impact factor: 49.962

3.  Induction by manganese of mitochondrial antibiotic resistance mutations in yeast.

Authors:  A Putrament; H Baranowska; W Prazmo
Journal:  Mol Gen Genet       Date:  1973-11-22

4.  Studies on deoxyribonucleic acid polymerases from yeast. 2. Partial purification and characterization of mitochondrial DNA polymerase from wild type and respiration-deficient yeast cells.

Authors:  U Wintersberger; E Wintersberger
Journal:  Eur J Biochem       Date:  1970-03-01

5.  The differential effect of magnesium and manganese ions on the synthesis of poly (dGd.C) and Micrococcus luteus DNA by Micrococcus luteus DNA polymerase.

Authors:  R M Litman
Journal:  J Mol Biol       Date:  1971-10-14       Impact factor: 5.469

6.  Mutator gene studies in Escherichia coli.

Authors:  E C Cox; C Yanofsky
Journal:  J Bacteriol       Date:  1969-10       Impact factor: 3.490

7.  Preferential synthesis of yeast mitochondrial DNA in the absence of protein synthesis.

Authors:  L I Grossman; E S Goldring; J Marmur
Journal:  J Mol Biol       Date:  1969-12-28       Impact factor: 5.469

8.  Synthesis of mitochondrial and nuclear DNA in anerobically grown yeast during the development of mitochondrial function in response to oxygen.

Authors:  M Rabinowitz; G S Getz; J Casey; H Swift
Journal:  J Mol Biol       Date:  1969-05-14       Impact factor: 5.469

9.  Induction of the cytoplasmic petite mutation in Saccharomyces cerevisiae by the antibacterial antibiotics erythromycin and chloramphenicol.

Authors:  D H Williamson; N G Maroudas; D Wilkie
Journal:  Mol Gen Genet       Date:  1971

10.  Effect of reversible inhibition of deoxyribonucleic acid synthesis on the yeast cell cycle.

Authors:  M L Slater
Journal:  J Bacteriol       Date:  1973-01       Impact factor: 3.490
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  7 in total

1.  New antibiotic resistance Loci in the ribosomal region of yeast mitochondrial DNA.

Authors:  J A Knight
Journal:  Genetics       Date:  1980-01       Impact factor: 4.562

2.  RNA splicing in yeast mitochondria: DNA sequence analysis of mit- mutants deficient in the excision of introns aI1 and aI2 of the gene for subunit I of cytochrome c oxidase.

Authors:  R van der Veen; M de Haan; L A Grivell
Journal:  Curr Genet       Date:  1988-03       Impact factor: 3.886

3.  Manganese toxicity to fungi: influence of pH.

Authors:  H Babich; G Stotzky
Journal:  Bull Environ Contam Toxicol       Date:  1981-10       Impact factor: 2.151

4.  Manganese mutagenesis in yeast. VI. Mn2+ uptake, mitDNA replication and ER induction: comparison with other divalent cations.

Authors:  A Putrament; H Baranowska; A Ejchart; W Jachymczyk
Journal:  Mol Gen Genet       Date:  1977-02-28

5.  Mitochondrial and nuclear myxothiazol resistance in Saccharomyces cerevisiae.

Authors:  G Thierbach; G Michaelis
Journal:  Mol Gen Genet       Date:  1982

6.  A cytoplasmic gene for partial suppression of a nuclear pleiotropic respiratory deficient mutant in the petite negative yeast Schizosaccharomyces pombe.

Authors:  A M Colson; F Labaille; A Goffeau
Journal:  Mol Gen Genet       Date:  1976-11-24

Review 7.  Role of cobalt, iron, lead, manganese, mercury, platinum, selenium, and titanium in carcinogenesis.

Authors:  G Kazantzis
Journal:  Environ Health Perspect       Date:  1981-08       Impact factor: 9.031
  7 in total

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