OBJECTIVE: The purpose of this prospective, randomized, double-blind study was to determine the effect of penicillin on pain in untreated teeth diagnosed with irreversible pulpitis. STUDY DESIGN:Forty emergency patients participated, and each had a clinical diagnosis of an irreversible pulpitis. Patients randomly received a 7-day oral dose (28 capsules, 500 mg each, to be taken every 6 hours) of either penicillin or a placebo control in a double-blind manner. No endodontic treatment was performed. Each patient also received ibuprofen; acetaminophen with codeine (30 mg); and a 7-day diary to record pain, percussion pain, and number and type of pain medication taken. RESULTS: The administration of penicillin did not significantly (P >.05) reduce pain, percussion pain, or the number of analgesic medications taken by patients with untreated irreversible pulpitis. The majority of patients with untreated irreversible pulpitis had significant pain and required analgesics to manage this pain. CONCLUSION:Penicillin should not be prescribed for untreated irreversible pulpitis because penicillin is ineffective for pain relief.
RCT Entities:
OBJECTIVE: The purpose of this prospective, randomized, double-blind study was to determine the effect of penicillin on pain in untreated teeth diagnosed with irreversible pulpitis. STUDY DESIGN: Forty emergency patients participated, and each had a clinical diagnosis of an irreversible pulpitis. Patients randomly received a 7-day oral dose (28 capsules, 500 mg each, to be taken every 6 hours) of either penicillin or a placebo control in a double-blind manner. No endodontic treatment was performed. Each patient also received ibuprofen; acetaminophen with codeine (30 mg); and a 7-day diary to record pain, percussion pain, and number and type of pain medication taken. RESULTS: The administration of penicillin did not significantly (P >.05) reduce pain, percussion pain, or the number of analgesic medications taken by patients with untreated irreversible pulpitis. The majority of patients with untreated irreversible pulpitis had significant pain and required analgesics to manage this pain. CONCLUSION:Penicillin should not be prescribed for untreated irreversible pulpitis because penicillin is ineffective for pain relief.
Authors: Malavika P Tampi; Lauren Pilcher; Olivia Urquhart; Erinne Kennedy; Kelly K O'Brien; Peter B Lockhart; Elliot Abt; Anita Aminoshariae; Michael J Durkin; Ashraf F Fouad; Prerna Gopal; Benjamin W Hatten; Melanie S Lang; Lauren L Patton; Thomas Paumier; Katie J Suda; Hannah Cho; Alonso Carrasco-Labra Journal: J Am Dent Assoc Date: 2019-12 Impact factor: 3.634
Authors: Sheela B Abraham; Nizam Abdulla; Wan Harun Himratul-Aznita; Manal Awad; Lakshman Perera Samaranayake; Hany Mohamed Aly Ahmed Journal: PLoS One Date: 2020-12-30 Impact factor: 3.240
Authors: Peter B Lockhart; Malavika P Tampi; Elliot Abt; Anita Aminoshariae; Michael J Durkin; Ashraf F Fouad; Prerna Gopal; Benjamin W Hatten; Erinne Kennedy; Melanie S Lang; Lauren L Patton; Thomas Paumier; Katie J Suda; Lauren Pilcher; Olivia Urquhart; Kelly K O'Brien; Alonso Carrasco-Labra Journal: J Am Dent Assoc Date: 2019-11 Impact factor: 3.634