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Literature DB >> 11076571

A new indanone from the marine cyanobacterium Lyngbya majuscula that inhibits hypoxia-induced activation of the VEGF promoter in Hep3B cells.

D G Nagle¹, Y D Zhou, P U Park, V J Paul, I Rajbhandari, C J Duncan, D S Pasco.

Abstract

A new indanone (1) has been isolated from the filamentous marine cyanobacterium Lyngbya majuscula, and its structure determined spectroscopically. Vascular endothelial growth factor (VEGF) is an important regulator of tumor angiogenesis. Compound 1 inhibits hypoxia-induced activation of the VEGF gene promoter in Hep3B human liver tumor cells, in vitro.

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Year: 2000 PMID： 11076571 DOI： 10.1021/np000216e

Source DB: PubMed Journal: J Nat Prod ISSN： 0163-3864 Impact factor: 4.050

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Cited

8 in total

1. 1-Indanone retards cyst development in ADPKD mouse model by stabilizing tubulin and down-regulating anterograde transport of cilia.

Authors: Xiao-Wei Li; Jian-Hua Ran; Hong Zhou; Jin-Zhao He; Zhi-Wei Qiu; Shu-Yuan Wang; Meng-Na Wu; Shuai Zhu; Yong-Pan An; Ang Ma; Min Li; Ya-Zhu Quan; Nan-Nan Li; Chao-Qun Ren; Bao-Xue Yang
Journal: Acta Pharmacol Sin Date: 2022-07-29 Impact factor: 7.169

Review 2. Mechanism targeted discovery of antitumor marine natural products.

Authors: Dale G Nagle; Yu-Dong Zhou; Flor D Mora; Kaleem A Mohammed; Yong-Pil Kim
Journal: Curr Med Chem Date: 2004-07 Impact factor: 4.530

3. Morphological, chemical, and genetic diversity of tropical marine cyanobacteria Lyngbya spp. and Symploca spp. (Oscillatoriales).

Authors: Robert W Thacker; Valerie J Paul
Journal: Appl Environ Microbiol Date: 2004-06 Impact factor: 4.792

Review 4. Synthesis of 1-indanones with a broad range of biological activity.

Authors: Marika Turek; Dorota Szczęsna; Marek Koprowski; Piotr Bałczewski
Journal: Beilstein J Org Chem Date: 2017-03-09 Impact factor: 2.883

5. Current Status on the Functional Characterization of Chemosensory Receptors of Cydia pomonella (Lepidoptera: Tortricidae).

Authors: Alberto Maria Cattaneo
Journal: Front Behav Neurosci Date: 2018-08-27 Impact factor: 3.558

A new indanone from the marine cyanobacterium Lyngbya majuscula that inhibits hypoxia-induced activation of the VEGF promoter in Hep3B cells.

1. 1-Indanone retards cyst development in ADPKD mouse model by stabilizing tubulin and down-regulating anterograde transport of cilia.

Review 2. Mechanism targeted discovery of antitumor marine natural products.

3. Morphological, chemical, and genetic diversity of tropical marine cyanobacteria Lyngbya spp. and Symploca spp. (Oscillatoriales).

Review 4. Synthesis of 1-indanones with a broad range of biological activity.

5. Current Status on the Functional Characterization of Chemosensory Receptors of Cydia pomonella (Lepidoptera: Tortricidae).

6. Copper-Catalyzed Annulation-Cyanotrifluoromethylation of 1,6-Enynes Toward 1-Indanones via a Radical Process.

7. In vitro and in silico insights into tyrosinase inhibitors with (E)-benzylidene-1-indanone derivatives.

Review 8. Recent applications of ninhydrin in multicomponent reactions.