| Literature DB >> 11076547 |
G Bringmann1, C Günther, W Saeb, J Mies, A Wickramasinghe, V Mudogo, R Brun.
Abstract
Three new naphthylisoquinoline alkaloids, ancistrolikokines A-C (1-3), have been isolated and structurally assigned from Ancistrocladus likoko, as well as the known compound korupensamine A (4). Their 5,8'-coupling hints at a close biogenetic relationship of A. likoko to other Central African Ancistrocladus species. Compounds 1-4 showed good to moderate antimalarial activities when evaluated in vitro against the NF54 and K1 strains of Plasmodium falciparum.Entities:
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Year: 2000 PMID： 11076547 DOI： 10.1021/np000199t
Source DB: PubMed Journal: J Nat Prod ISSN： 0163-3864 Impact factor: 4.050