OBJECTIVE: To discover whether tobacco smoking and intake of different types of alcoholic drinks are associated with small bowel adenocarcinoma (SBA). METHODS: A population-based European multi-center case-control study was conducted from 1995 to 1997. RESULTS: After a histological review using uniform diagnostic criteria, 47 (33%) of the 142 identified cases of SBA were excluded due to reclassification as either tumors of the papilla of Vater (n = 22), stromal tumors, or metastases; 95 cases were accepted for study. In all, 70 cases of SBA together with 2070 controls matched by age, sex, and region were interviewed. A high intake (more than 24 g alcohol per day) of beer or spirits was associated with SBA, an odds ratio (OR) of 3.5 and 95% confidence intervals (CI) of 1.5-8.0 and 3.4 (95% CI 1.3-9.2), respectively). There was no association with wine intake or total alcohol intake. Tobacco smoking was probably unrelated to SBA. CONCLUSIONS: A high intake of beer or spirits seems to be a risk factor for SBA. Since this association was not seen for wine drinkers, protective components of wine may counterbalance a carcinogenic effect of alcohol on the small bowel. Alternatively, the result may be confounded by other factors, e.g. dietary factors.
OBJECTIVE: To discover whether tobacco smoking and intake of different types of alcoholic drinks are associated with small bowel adenocarcinoma (SBA). METHODS: A population-based European multi-center case-control study was conducted from 1995 to 1997. RESULTS: After a histological review using uniform diagnostic criteria, 47 (33%) of the 142 identified cases of SBA were excluded due to reclassification as either tumors of the papilla of Vater (n = 22), stromal tumors, or metastases; 95 cases were accepted for study. In all, 70 cases of SBA together with 2070 controls matched by age, sex, and region were interviewed. A high intake (more than 24 g alcohol per day) of beer or spirits was associated with SBA, an odds ratio (OR) of 3.5 and 95% confidence intervals (CI) of 1.5-8.0 and 3.4 (95% CI 1.3-9.2), respectively). There was no association with wine intake or total alcohol intake. Tobacco smoking was probably unrelated to SBA. CONCLUSIONS: A high intake of beer or spirits seems to be a risk factor for SBA. Since this association was not seen for wine drinkers, protective components of wine may counterbalance a carcinogenic effect of alcohol on the small bowel. Alternatively, the result may be confounded by other factors, e.g. dietary factors.
Authors: P Boffetta; W D Hazelton; Y Chen; R Sinha; M Inoue; Y T Gao; W P Koh; X O Shu; E J Grant; I Tsuji; Y Nishino; S L You; K Y Yoo; J M Yuan; J Kim; S Tsugane; G Yang; R Wang; Y B Xiang; K Ozasa; M Nagai; M Kakizaki; C J Chen; S K Park; A Shin; H Ahsan; C X Qu; J E Lee; M Thornquist; B Rolland; Z Feng; W Zheng; J D Potter Journal: Ann Oncol Date: 2011-12-06 Impact factor: 32.976
Authors: Michael J Overman; Chung-Yuan Hu; Scott Kopetz; James L Abbruzzese; Robert A Wolff; George J Chang Journal: Ann Surg Oncol Date: 2011-12-21 Impact factor: 5.344
Authors: Amanda J Cross; Michael F Leitzmann; Amy F Subar; Frances E Thompson; Albert R Hollenbeck; Arthur Schatzkin Journal: Cancer Res Date: 2008-11-15 Impact factor: 12.701