| Literature DB >> 1107548 |
Abstract
A striking difference in antimalarial activity between the diastereomers of 6-bromo-alpha-[2-(1-methylpiperidyl)]-9-phenanthrenemethanol, alpha-(3-peperidyl)-3,6-bis(trifluoromethyl)-9-phenanthrenemethanol, and alpha-(3-piperidyl)-2,8-bis(trifluoromethyl)-4-quinolinemethanol was observed. A possible explanation involving the N-O distance and active site binding requirements is suggested.Entities:
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Year: 1976 PMID： 1107548 DOI： 10.1021/jm00223a032
Source DB: PubMed Journal: J Med Chem ISSN： 0022-2623 Impact factor: 7.446