Literature DB >> 11073937

Genetic analysis of peptidoglycan biosynthesis in mycobacteria: characterization of a ddlA mutant of Mycobacterium smegmatis.

A E Belanger1, J C Porter, G F Hatfull.   

Abstract

A temperature-sensitive mutant of Mycobacterium smegmatis was characterized that contains a mutation in ddlA, the gene encoding D-alanine:D-alanine ligase. Enzymatic assays using recombinant proteins and D-cycloserine susceptibility indicate that the A365V mutation in the SMEG35 DdlA protein causes a reduction in enzymatic activity in vitro and in vivo.

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Year:  2000        PMID： 11073937      PMCID： PMC111435          DOI： 10.1128/JB.182.23.6854-6856.2000

Source DB:  PubMed          Journal:  J Bacteriol        ISSN： 0021-9193            Impact factor:   3.490


  19 in total

1.  THE ENZYMATIC SYNTHESIS OF D-ALANYL-D-ALANINE. 3. ON THE INHIBITION OF D-ALANYL-D-ALANINE SYNTHETASE BY THE ANTIBIOTIC D-CYCLOSERINE.

Authors:  F C NEUHAUS; J L LYNCH
Journal:  Biochemistry       Date:  1964-04       Impact factor: 3.162

2.  Exponential-phase glycogen recycling is essential for growth of Mycobacterium smegmatis.

Authors:  A E Belanger; G F Hatfull
Journal:  J Bacteriol       Date:  1999-11       Impact factor: 3.490

3.  Cell wall peptidoglycan mutants of Escherichia coli K-12: existence of two clusters of genes, mra and mrb, for cell wall peptidoglycan biosynthesis.

Authors:  T Miyakawa; H Matsuzawa; M Matsuhashi; Y Sugino
Journal:  J Bacteriol       Date:  1972-11       Impact factor: 3.490

4.  Temperature-sensitive mutants of Escherichia coli K-12 with low activities of the L-alanine adding enzyme and the D-alanyl-D-alanine adding enzyme.

Authors:  E J Lugtenberg; A v Schijndel-van Dam
Journal:  J Bacteriol       Date:  1972-04       Impact factor: 3.490

5.  Susceptibility of mycobacterial D-alanyl-D-alanine synthetase to D-cycloserine.

Authors:  H L David; K Takayama; D S Goldman
Journal:  Am Rev Respir Dis       Date:  1969-10

6.  Isolation and characterization of efficient plasmid transformation mutants of Mycobacterium smegmatis.

Authors:  S B Snapper; R E Melton; S Mustafa; T Kieser; W R Jacobs
Journal:  Mol Microbiol       Date:  1990-11       Impact factor: 3.501

7.  Isolation, cloning, and sequencing of the Salmonella typhimurium ddlA gene with purification and characterization of its product, D-alanine:D-alanine ligase (ADP forming).

Authors:  E Daub; L E Zawadzke; D Botstein; C T Walsh
Journal:  Biochemistry       Date:  1988-05-17       Impact factor: 3.162

8.  Murein synthesis and identification of cell wall precursors of temperature-sensitive lysis mutants of Escherichia coli.

Authors:  E J Lugtenberg; L De Haas-Menger; W H Ruyters
Journal:  J Bacteriol       Date:  1972-01       Impact factor: 3.490

9.  Superinfection immunity of mycobacteriophage L5: applications for genetic transformation of mycobacteria.

Authors:  M K Donnelly-Wu; W R Jacobs; G F Hatfull
Journal:  Mol Microbiol       Date:  1993-02       Impact factor: 3.501

10.  Existence of two D-alanine:D-alanine ligases in Escherichia coli: cloning and sequencing of the ddlA gene and purification and characterization of the DdlA and DdlB enzymes.

Authors:  L E Zawadzke; T D Bugg; C T Walsh
Journal:  Biochemistry       Date:  1991-02-12       Impact factor: 3.162
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  8 in total

1.  Mycobacterium smegmatis D-Alanine Racemase Mutants Are Not Dependent on D-Alanine for Growth.

Authors:  Ofelia Chacon; Zhengyu Feng; N Beth Harris; Nancy E Cáceres; L Garry Adams; Raúl G Barletta
Journal:  Antimicrob Agents Chemother       Date:  2002-01       Impact factor: 5.191

2.  N Glycolylation of the nucleotide precursors of peptidoglycan biosynthesis of Mycobacterium spp. is altered by drug treatment.

Authors:  Sebabrata Mahapatra; Hataichanok Scherman; Patrick J Brennan; Dean C Crick
Journal:  J Bacteriol       Date:  2005-04       Impact factor: 3.490

3.  Assessment of Metabolic Changes in Mycobacterium smegmatis Wild-Type and alr Mutant Strains: Evidence of a New Pathway of d-Alanine Biosynthesis.

Authors:  Darrell D Marshall; Steven Halouska; Denise K Zinniel; Robert J Fenton; Katie Kenealy; Harpreet K Chahal; Govardhan Rathnaiah; Raúl G Barletta; Robert Powers
Journal:  J Proteome Res       Date:  2017-02-14       Impact factor: 4.466

4.  Structure of the Mycobacterium tuberculosis D-alanine:D-alanine ligase, a target of the antituberculosis drug D-cycloserine.

Authors:  John B Bruning; Ana C Murillo; Ofelia Chacon; Raúl G Barletta; James C Sacchettini
Journal:  Antimicrob Agents Chemother       Date:  2010-10-18       Impact factor: 5.191

5.  Roles of Mycobacterium smegmatis D-alanine:D-alanine ligase and D-alanine racemase in the mechanisms of action of and resistance to the peptidoglycan inhibitor D-cycloserine.

Authors:  Zhengyu Feng; Raúl G Barletta
Journal:  Antimicrob Agents Chemother       Date:  2003-01       Impact factor: 5.191

6.  In silico optimization of a fragment-based hit yields biologically active, high-efficiency inhibitors for glutamate racemase.

Authors:  Katie L Whalen; Anthony C Chau; M Ashley Spies
Journal:  ChemMedChem       Date:  2013-08-08       Impact factor: 3.466

7.  Peptidoglycan precursor synthesis along the sidewall of pole-growing mycobacteria.

Authors:  Alam García-Heredia; Amol Arunrao Pohane; Emily S Melzer; Caleb R Carr; Taylor J Fiolek; Sarah R Rundell; Hoong Chuin Lim; Jeffrey C Wagner; Yasu S Morita; Benjamin M Swarts; M Sloan Siegrist
Journal:  Elife       Date:  2018-09-10       Impact factor: 8.140

8.  A point mutation in cycA partially contributes to the D-cycloserine resistance trait of Mycobacterium bovis BCG vaccine strains.

Authors:  Jeffrey M Chen; Swapna Uplekar; Stephen V Gordon; Stewart T Cole
Journal:  PLoS One       Date:  2012-08-17       Impact factor: 3.240
  8 in total

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