Literature DB >> 11073677

Synthesis and deprotection of oligonucleotides under aprotic conditions.

T Chen1, J Fu, M M Greenberg.   

Abstract

Oligonucleotides containing an alkali-labile nucleotide are synthesized and deprotected using a synthetic method that eliminates the use of Bronsted acid and base. The development of a new family of exocyclic amine-protecting groups is an integral component of this approach.

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Year:  2000        PMID: 11073677     DOI: 10.1021/ol006604p

Source DB:  PubMed          Journal:  Org Lett        ISSN: 1523-7052            Impact factor:   6.005


  2 in total

1.  Efficient synthesis of exo-N-carbamoyl nucleosides: application to the synthesis of phosphoramidate prodrugs.

Authors:  Jong Hyun Cho; Steven J Coats; Raymond F Schinazi
Journal:  Org Lett       Date:  2012-05-03       Impact factor: 6.005

2.  Solid-phase synthesis and hybrization behavior of partially 2'/3'-O-acetylated RNA oligonucleotides.

Authors:  Jianfeng Xu; Colm D Duffy; Christopher K W Chan; John D Sutherland
Journal:  J Org Chem       Date:  2014-03-31       Impact factor: 4.354

  2 in total

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