Literature DB >> 11073153

Cloning and analysis of genomic differences unique to Burkholderia pseudomallei by comparison with B. thailandensis.

Nat F Brown1, Ifor R Beacham1.   

Abstract

Melioidosis is an infectious disease caused by Burkholderia pseudomallei. Genomic subtractive hybridisation was performed with the closely related avirulent species B. thailandensis to identify virulence genes of B. pseudomallei. The subtractive hybridisation products were highly specific for B. pseudomallei. Sequence analysis revealed a number of putative virulence factors, as well as apparently novel sequences of unknown function. The subtracted library contained DNA regions of relatively low G + C mol% content, which were distributed throughout the B. pseudomallei genome. The distribution of subtracted sequences amongst a collection of 22 B. pseudomallei isolates was found to be variable, with the exception of three strains which almost universally lacked the subtracted sequences. These three strains also differed in that they were highly haemolytic, indicating a possible separate virotype.

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Year:  2000        PMID： 11073153     DOI： 10.1099/0022-1317-49-11-993

Source DB:  PubMed          Journal:  J Med Microbiol        ISSN： 0022-2615            Impact factor:   2.472


  12 in total

1.  Adherence of Burkholderia pseudomallei cells to cultured human epithelial cell lines is regulated by growth temperature.

Authors:  Nat F Brown; Justin A Boddey; Cameron P Flegg; Ifor R Beacham
Journal:  Infect Immun       Date:  2002-02       Impact factor: 3.441

2.  Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.

Authors:  Matthew T G Holden; Richard W Titball; Sharon J Peacock; Ana M Cerdeño-Tárraga; Timothy Atkins; Lisa C Crossman; Tyrone Pitt; Carol Churcher; Karen Mungall; Stephen D Bentley; Mohammed Sebaihia; Nicholas R Thomson; Nathalie Bason; Ifor R Beacham; Karen Brooks; Katherine A Brown; Nat F Brown; Greg L Challis; Inna Cherevach; Tracy Chillingworth; Ann Cronin; Ben Crossett; Paul Davis; David DeShazer; Theresa Feltwell; Audrey Fraser; Zahra Hance; Heidi Hauser; Simon Holroyd; Kay Jagels; Karen E Keith; Mark Maddison; Sharon Moule; Claire Price; Michael A Quail; Ester Rabbinowitsch; Kim Rutherford; Mandy Sanders; Mark Simmonds; Sirirurg Songsivilai; Kim Stevens; Sarinna Tumapa; Monkgol Vesaratchavest; Sally Whitehead; Corin Yeats; Bart G Barrell; Petra C F Oyston; Julian Parkhill
Journal:  Proc Natl Acad Sci U S A       Date:  2004-09-17       Impact factor: 11.205

3.  A type IV pilin, PilA, Contributes To Adherence of Burkholderia pseudomallei and virulence in vivo.

Authors:  Angela E Essex-Lopresti; Justin A Boddey; Richard Thomas; Martin P Smith; M Gill Hartley; Timothy Atkins; Nat F Brown; Chuk Hai Tsang; Ian R A Peak; Jim Hill; Ifor R Beacham; Richard W Titball
Journal:  Infect Immun       Date:  2005-02       Impact factor: 3.441

4.  Genetic differences between blight-causing Erwinia species with differing host specificities, identified by suppression subtractive hybridization.

Authors:  Lindsay R Triplett; Youfu Zhao; George W Sundin
Journal:  Appl Environ Microbiol       Date:  2006-09-08       Impact factor: 4.792

5.  Temperature-regulated microcolony formation by Burkholderia pseudomallei requires pilA and enhances association with cultured human cells.

Authors:  Justin A Boddey; Cameron P Flegg; Chris J Day; Ifor R Beacham; Ian R Peak
Journal:  Infect Immun       Date:  2006-09       Impact factor: 3.441

6.  Identification of a novel two-partner secretion system from Burkholderia pseudomallei.

Authors:  N F Brown; C-A Logue; J A Boddey; R Scott; R G Hirst; I R Beacham
Journal:  Mol Genet Genomics       Date:  2004-08-13       Impact factor: 3.291

7.  Burkholderia pseudomallei Capsule Exacerbates Respiratory Melioidosis but Does Not Afford Protection against Antimicrobial Signaling or Bacterial Killing in Human Olfactory Ensheathing Cells.

Authors:  Samantha J Dando; Deepak S Ipe; Michael Batzloff; Matthew J Sullivan; David K Crossman; Michael Crowley; Emily Strong; Stephanie Kyan; Sophie Y Leclercq; Jenny A K Ekberg; James St John; Ifor R Beacham; Glen C Ulett
Journal:  Infect Immun       Date:  2016-06-23       Impact factor: 3.441

8.  Genomic diversity of Burkholderia pseudomallei clinical isolates: subtractive hybridization reveals a Burkholderia mallei-specific prophage in B. pseudomallei 1026b.

Authors:  David DeShazer
Journal:  J Bacteriol       Date:  2004-06       Impact factor: 3.490

9.  Burkholderia pseudomallei Rapidly Infects the Brain Stem and Spinal Cord via the Trigeminal Nerve after Intranasal Inoculation.

Authors:  James A St John; Heidi Walkden; Lynn Nazareth; Kenneth W Beagley; Glen C Ulett; Michael R Batzloff; Ifor R Beacham; Jenny A K Ekberg
Journal:  Infect Immun       Date:  2016-08-19       Impact factor: 3.441

10.  Quorum sensing negatively regulates multinucleate cell formation during intracellular growth of Burkholderia pseudomallei in macrophage-like cells.

Authors:  Rachel E Horton; Gary D Grant; Ben Matthews; Michael Batzloff; Suzzanne J Owen; Stephanie Kyan; Cameron P Flegg; Amanda M Clark; Glen C Ulett; Nigel Morrison; Ian R Peak; Ifor R Beacham
Journal:  PLoS One       Date:  2013-05-21       Impact factor: 3.240
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