Literature DB >> 11073024

Hospital disinfectants and spore formation by Clostridium difficile.

M H Wilcox, W N Fawley.   

Abstract

Evidence is lacking on how best to decontaminate the hospital environment of Clostridium difficile. We compared sporulation levels in the UK epidemic C. difficile strain (P24), another clinical isolate (B31), and an environmental strain (E4) cultured in faecal emulsion containing subinhibitory concentrations of one of five hospital cleaning agents. The epidemic strain produced significantly more spores than the non-prevalent strains, and sporulation was further enhanced when this strain was cultured in faeces exposed to non-chlorine-based cleaning agents. The choice of cleaning agent can have a substantial effect on the persistence of C. difficile spores in the hospital environment.

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Year:  2000        PMID： 11073024     DOI： 10.1016/S0140-6736(00)02819-1

Source DB:  PubMed          Journal:  Lancet        ISSN： 0140-6736            Impact factor:   79.321


  36 in total

1.  The effects of storage conditions on viability of Clostridium difficile vegetative cells and spores and toxin activity in human faeces.

Authors:  J Freeman; M H Wilcox
Journal:  J Clin Pathol       Date:  2003-02       Impact factor: 3.411

2.  Lack of association between clinical outcome of Clostridium difficile infections, strain type, and virulence-associated phenotypes.

Authors:  Stéphanie Sirard; Louis Valiquette; Louis-Charles Fortier
Journal:  J Clin Microbiol       Date:  2011-09-28       Impact factor: 5.948

Review 3.  Recognition and prevention of hospital-associated enteric infections in the intensive care unit.

Authors:  Linda D Bobo; Erik R Dubberke
Journal:  Crit Care Med       Date:  2010-08       Impact factor: 7.598

4.  Molecular and microbiological characterization of Clostridium difficile isolates from single, relapse, and reinfection cases.

Authors:  Kentaro Oka; Takako Osaki; Tomoko Hanawa; Satoshi Kurata; Mitsuhiro Okazaki; Taki Manzoku; Motomichi Takahashi; Mamoru Tanaka; Haruhiko Taguchi; Takashi Watanabe; Takashi Inamatsu; Shigeru Kamiya
Journal:  J Clin Microbiol       Date:  2012-01-11       Impact factor: 5.948

5.  Increased rate of DNA recovery from United Kingdom epidemic Clostridium difficile PCR ribotype 1 strains stored cryogenically.

Authors:  N J Asha; W N Fawley; J Freeman; M H Wilcox
Journal:  J Clin Microbiol       Date:  2005-11       Impact factor: 5.948

6.  Molecular epidemiology of endemic Clostridium difficile infection and the significance of subtypes of the United Kingdom epidemic strain (PCR ribotype 1).

Authors:  Warren N Fawley; Peter Parnell; Paul Verity; Jane Freeman; Mark H Wilcox
Journal:  J Clin Microbiol       Date:  2005-06       Impact factor: 5.948

Review 7.  The changing epidemiology of Clostridium difficile infections.

Authors:  J Freeman; M P Bauer; S D Baines; J Corver; W N Fawley; B Goorhuis; E J Kuijper; M H Wilcox
Journal:  Clin Microbiol Rev       Date:  2010-07       Impact factor: 26.132

Review 8.  Clostridium difficile Infection in Children: Current State and Unanswered Questions.

Authors:  Pranita D Tamma; Thomas J Sandora
Journal:  J Pediatric Infect Dis Soc       Date:  2012-07-25       Impact factor: 3.164

9.  Use of highly discriminatory fingerprinting to analyze clusters of Clostridium difficile infection cases due to epidemic ribotype 027 strains.

Authors:  W N Fawley; J Freeman; C Smith; C Harmanus; R J van den Berg; E J Kuijper; M H Wilcox
Journal:  J Clin Microbiol       Date:  2008-01-23       Impact factor: 5.948

10.  Newly identified bacteriolytic enzymes that target a wide range of clinical isolates of Clostridium difficile.

Authors:  Krunal K Mehta; Elena E Paskaleva; Xia Wu; Navdeep Grover; Ruchir V Mundra; Kevin Chen; Yongrong Zhang; Zhiyong Yang; Hanping Feng; Jonathan S Dordick; Ravi S Kane
Journal:  Biotechnol Bioeng       Date:  2016-06-20       Impact factor: 4.530
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