Vascular dementia, a new beginning: shifting focus from clinical phenotype to ischemic brain injury.

Dementia may result from complete or incomplete infarction of brain regions subserving memory and cognition. Several effective treatments reduce the risk of initial and recurrent stroke. Presumably, these interventions reduce the risk of vascular cognitive impairment. Incomplete infarction caused by recurrent, chronic, or subclinical ischemia appears to represent another important cause of ischemic brain injury, but has been relatively neglected. A shift in focus from the serendipitous clinical phenotype of vascular dementia to preventing and ameliorating the broad spectrum of ischemic brain injury is recommended.