Literature DB >> 11072262

Treatment of Alzheimer's disease: rationale and strategies.

M Grundman1, L J Thal.   

Abstract

This article reviews the rationale and provides a progress update regarding the major treatment strategies being developed for the prevention and treatment of Alzheimer's disease. Various therapeutic areas are discussed, including acetylcholinesterase inhibitors and other cholinergic agents, antioxidants, anti-inflammatory drugs, hormone replacement therapy, antiamyloid treatment, and neurotrophic agents.

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Year:  2000        PMID： 11072262     DOI： 10.1016/s0733-8619(05)70227-9

Source DB:  PubMed          Journal:  Neurol Clin        ISSN： 0733-8619            Impact factor:   3.806


  4 in total

1.  A novel beta-sheet breaker, RS-0406, reverses amyloid beta-induced cytotoxicity and impairment of long-term potentiation in vitro.

Authors:  Yasuhiro Nakagami; Satoko Nishimura; Takako Murasugi; Isao Kaneko; Masaki Meguro; Shinji Marumoto; Hiroshi Kogen; Kazuo Koyama; Tomiichiro Oda
Journal:  Br J Pharmacol       Date:  2002-11       Impact factor: 8.739

2.  Discovery and structure activity relationship of small molecule inhibitors of toxic β-amyloid-42 fibril formation.

Authors:  Heiko Kroth; Annalisa Ansaloni; Yvan Varisco; Asad Jan; Nampally Sreenivasachary; Nasrollah Rezaei-Ghaleh; Valérie Giriens; Sophie Lohmann; María Pilar López-Deber; Oskar Adolfsson; Maria Pihlgren; Paolo Paganetti; Wolfgang Froestl; Luitgard Nagel-Steger; Dieter Willbold; Thomas Schrader; Markus Zweckstetter; Andrea Pfeifer; Hilal A Lashuel; Andreas Muhs
Journal:  J Biol Chem       Date:  2012-08-13       Impact factor: 5.157

Review 3.  Potential treatment opportunities for Alzheimer's disease through inhibition of secretases and Abeta immunization.

Authors:  D Schenk; D Games; P Seubert
Journal:  J Mol Neurosci       Date:  2001-10       Impact factor: 3.444

4.  Alzheimer's amyloid-β A2T variant and its N-terminal peptides inhibit amyloid-β fibrillization and rescue the induced cytotoxicity.

Authors:  Tien-Wei Lin; Chi-Fon Chang; Yu-Jen Chang; Yi-Hung Liao; Hui-Ming Yu; Yun-Ru Chen
Journal:  PLoS One       Date:  2017-03-31       Impact factor: 3.240
  4 in total

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